The diagnosis of GH deficiency (GHD) is based on the measurement of peak GH responses to pharmacological stimuli. Pharmacological stimuli, however, lack precision, accuracy, are not reproducible, are invasive, non-physiological and some may even be hazardous. Furthermore, different GH commercial assays used to measure GH in serum yield results that may differ considerably. In contrast to GH, IGF-I can be measured on a single, randomly-obtained blood sample. A review of the available data indicates that IGF-I measurement in the diagnosis of childhood-onset isolated GHD has a specificity of up to 100%, with a sensitivity ranging from about 70 to 90%. We suggest an algorithm in which circulating levels of IGF-I together with the evaluation of auxological data, such as growth rate and growth, may be used to assess the likelihood of GHD in pre-pubertal children.
The diagnosis of GH deficiency (GHD) is based on the measurement of peak GH responses to pharmacological stimuli. Pharmacological stimuli, however, lack precision, accuracy, are not reproducible, are invasive, non-physiological and some may even be hazardous. Furthermore, different GH commercial assays used to measure GH in serum yield results that may differ considerably. In contrast to GH, IGF-I can be measured on a single, randomly-obtained blood sample. A review of the available data indicates that IGF-I measurement in the diagnosis of childhood-onset isolated GHD has a specificity of up to 100%, with a sensitivity ranging from about 70 to 90%. We suggest an algorithm in which circulating levels of IGF-I together with the evaluation of auxological data, such as growth rate and growth, may be used to assess the likelihood of GHD in pre-pubertal children.
Assesment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: A proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED) / Federico, G.; Street, M. E.; Maghnie, M.; Caruso-Nicoletti, M.; Loche, S.; Bertelloni, S.; Cianfarani, S.; Cicognani, A.; Cesaretti, G.; Lorini, R.; Meschi, F.; de Sanctis, V.; Aimarretti, G.; Antoniazzi, F.; Arrigo, T.; Bellone, J.; Bellone, S.; Bertalloni, S.; Bozzola, M.; Buzi, F.; Cappa, M.; Cistemino, M.; De Luca, F.; Del Vecchio, M.; Galluzzi, F.; Germani, D.; Ghirri, P.; Ghizzoni, L.; Greggio, N. A.; Iughetti, L.; Losi, S.; Luciano, A.; Maffeis, C.; Modestini, E.; Pirazzoli, P.; Pozzobon, G.; Predieri, B.; Rusconi, R.; Slerno, M. C.; Salvatoni, A.; Scirè, G.; Scommegna, S.; Spadoni, G. L.; Sposito, M.; Wasniewska, M.; Zampolli, M.; Zucchini, S.. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - STAMPA. - 29:8(2006), pp. 732-737. [10.1007/BF03344184]
Assesment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: A proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED)
Iughetti L.;Predieri B.;
2006
Abstract
The diagnosis of GH deficiency (GHD) is based on the measurement of peak GH responses to pharmacological stimuli. Pharmacological stimuli, however, lack precision, accuracy, are not reproducible, are invasive, non-physiological and some may even be hazardous. Furthermore, different GH commercial assays used to measure GH in serum yield results that may differ considerably. In contrast to GH, IGF-I can be measured on a single, randomly-obtained blood sample. A review of the available data indicates that IGF-I measurement in the diagnosis of childhood-onset isolated GHD has a specificity of up to 100%, with a sensitivity ranging from about 70 to 90%. We suggest an algorithm in which circulating levels of IGF-I together with the evaluation of auxological data, such as growth rate and growth, may be used to assess the likelihood of GHD in pre-pubertal children.
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