The cellular activity of hemocytes from the marine mollusc Mytilus galloprovincialis was studied using computer-assisted microscopic image analysis. PDGF-AB and TGF-beta 1 caused changes in cellular shape and induced the immunocytes to migrate in a chemotactic manner. The effect of PDGF-AB was more potent than that of TGF-beta 1, and the responses were dose-correlated for PDGF-AB, while they were dose-dependent up to 5 pg/ml for TGF-beta 1. Moreover, the PDGF-AB response was extracellular Ca2+-independent, while TGF-beta 1 was Ca2+-dependent.
PDGF- and TGF-beta-induced changes in cell shape of invertebrate immunocytes: effect of calcium entry blockers / Ottaviani, Enzo; D., Sassi; D., Kletsas. - In: EUROPEAN JOURNAL OF CELL BIOLOGY. - ISSN 0171-9335. - STAMPA. - 74:(1997), pp. 336-341.
PDGF- and TGF-beta-induced changes in cell shape of invertebrate immunocytes: effect of calcium entry blockers
OTTAVIANI, Enzo;
1997
Abstract
The cellular activity of hemocytes from the marine mollusc Mytilus galloprovincialis was studied using computer-assisted microscopic image analysis. PDGF-AB and TGF-beta 1 caused changes in cellular shape and induced the immunocytes to migrate in a chemotactic manner. The effect of PDGF-AB was more potent than that of TGF-beta 1, and the responses were dose-correlated for PDGF-AB, while they were dose-dependent up to 5 pg/ml for TGF-beta 1. Moreover, the PDGF-AB response was extracellular Ca2+-independent, while TGF-beta 1 was Ca2+-dependent.
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