The purpose of the work was to examine in vivo the structural modifications and the translocation ability of Solid Lipid Nanoparticles (SLN) loaded with titanium or silicon dioxides across stratum corneum (SC) by EDX analysis. Intact SLN can translocate across SC until the corneum compactum where a biodegradation process can occur suggesting an interaction with the lipid packing between the corneocyte clusters supposed as the main pathway. Conversely, lipid microparticles were retained on the skin surface preventing the loaded metal dioxides from permeating the uppermost SC layers.
Detection of solid lipid nanoparticles in human stratum corneum by EDX analys / Iannuccelli, Valentina; Leo, Eliana Grazia; Sergi, Santo; Coppi, Gilberto. - STAMPA. - ND:(2012), pp. 95-95. (Intervento presentato al convegno Skin and Formulation - 4th Symposium tenutosi a Lione - Francia nel 4/5 giugno 2012).
Detection of solid lipid nanoparticles in human stratum corneum by EDX analys
IANNUCCELLI, Valentina;LEO, Eliana Grazia;SERGI, Santo;COPPI, Gilberto
2012
Abstract
The purpose of the work was to examine in vivo the structural modifications and the translocation ability of Solid Lipid Nanoparticles (SLN) loaded with titanium or silicon dioxides across stratum corneum (SC) by EDX analysis. Intact SLN can translocate across SC until the corneum compactum where a biodegradation process can occur suggesting an interaction with the lipid packing between the corneocyte clusters supposed as the main pathway. Conversely, lipid microparticles were retained on the skin surface preventing the loaded metal dioxides from permeating the uppermost SC layers.
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