The general approach of the so far developed technologies is the attempt to increase the homing rate of transplanted stem cells by modifying the molecules/receptors that interact directly with the chemokines/ligands in the damaged tissue. Our unique technology does not interact with the natural repertoire of specific molecules/receptors mediating homing of stem cells to the damaged tissue (SPECIFIC HOMING) but impairs the function of molecules/receptors that are responsible for the adhesion of stem cells throughout the non-damaged vasculature (NON-SPECIFIC CELL ADHESION). Moreover and most importantly, our highly effective technology is non-toxic, does not affect stem cell function and does not require genetic modifications thus making it a most promising candidate for clinical use
Targeting the homing of stem cells via suppression of cell adhesion in the peripheral vasculature / R., Schaefer; L., Danielyan; R., Kehlbach; R., Bantleon; G., Siegel; A., Ameln Mayerhofer; H. P., Wendel; T., Kluba; Dominici, Massimo; C. D., Claussen; H., Northoff. - .
Targeting the homing of stem cells via suppression of cell adhesion in the peripheral vasculature
DOMINICI, Massimo;
Abstract
The general approach of the so far developed technologies is the attempt to increase the homing rate of transplanted stem cells by modifying the molecules/receptors that interact directly with the chemokines/ligands in the damaged tissue. Our unique technology does not interact with the natural repertoire of specific molecules/receptors mediating homing of stem cells to the damaged tissue (SPECIFIC HOMING) but impairs the function of molecules/receptors that are responsible for the adhesion of stem cells throughout the non-damaged vasculature (NON-SPECIFIC CELL ADHESION). Moreover and most importantly, our highly effective technology is non-toxic, does not affect stem cell function and does not require genetic modifications thus making it a most promising candidate for clinical use
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