Ethanol stimulating transient receptor potential vanilloid 1 (TRPV1) on primary sensory neurons promotes release of calcitonin generelated peptide (CGRP)-mediated coronary dilation. Alcohol triggers migraine attacks . We have investigated in guinea pigs whether ethanol by TRPV1 stimulation, causes neurogenic inflammation in the trigeminovascular system. Moreover, Ethanol-evoked release of neuropeptides from slices of dura mater was abolished by capsaicin pretreatment . Intragastric ethanol increased plasma extravasation in dura mater This effect is abolished by capsazepine and SR140333, and by BIBN4096BS, a CGRP receptor antagonist.
Ethano causes neurogenic inflammation and vasodilation by TRPV1 activation and CGRP release in the trigeminovascular system in guinea pig / G., De Siena; P., Nicoletti; M., Trevisani; M., Manconi; G., Zagli; S., Benemei; J. A., Capone; Pini, Luigi Alberto; P., Geppetti. - In: NEUROPEPTIDES. - ISSN 0143-4179. - STAMPA. - 42:(2008), pp. 475-476. (Intervento presentato al convegno Conference on neuropetide function, disfunctions and therapeutic options tenutosi a Santorini- Greece nel Apr 19-21 2007).
Ethano causes neurogenic inflammation and vasodilation by TRPV1 activation and CGRP release in the trigeminovascular system in guinea pig
PINI, Luigi Alberto;
2008
Abstract
Ethanol stimulating transient receptor potential vanilloid 1 (TRPV1) on primary sensory neurons promotes release of calcitonin generelated peptide (CGRP)-mediated coronary dilation. Alcohol triggers migraine attacks . We have investigated in guinea pigs whether ethanol by TRPV1 stimulation, causes neurogenic inflammation in the trigeminovascular system. Moreover, Ethanol-evoked release of neuropeptides from slices of dura mater was abolished by capsaicin pretreatment . Intragastric ethanol increased plasma extravasation in dura mater This effect is abolished by capsazepine and SR140333, and by BIBN4096BS, a CGRP receptor antagonist.
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