Priamry hyeprcholesterolemai associates with increased rates of cholesterol 27 hydroxylation which normalizes with statin treatment. the correlation between plasma cholesterol levels and 27 hydroxylation support the view that the latter may act as a compensatory mechanism in a condition of larger plasma cholesterol pool. A regulatory roel for uclear receptors seems reasonable.These dta may encourage novel pharmacplogical approaches for the managment of hypercholesterolemia and prevention of atherosclerosis
Increase degradation of cholesterol via the alternate pathway of bile acid biosynthesis in primary hypercholesterolemia / Bertolotti, Marco; Del Puppo, M; Gabbi, C; Anzivino, Claudia; Carulli, Lucia; Galli Kienle, M; Carulli, N.. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - STAMPA. - 3:(2008), pp. 11-11. (Intervento presentato al convegno 109° Congresso nazionale della Società Italiana di Medician Interna tenutosi a Rome, Italy nel 25.10.2008).
Increase degradation of cholesterol via the alternate pathway of bile acid biosynthesis in primary hypercholesterolemia.
BERTOLOTTI, Marco;ANZIVINO, Claudia;CARULLI, Lucia;
2008
Abstract
Priamry hyeprcholesterolemai associates with increased rates of cholesterol 27 hydroxylation which normalizes with statin treatment. the correlation between plasma cholesterol levels and 27 hydroxylation support the view that the latter may act as a compensatory mechanism in a condition of larger plasma cholesterol pool. A regulatory roel for uclear receptors seems reasonable.These dta may encourage novel pharmacplogical approaches for the managment of hypercholesterolemia and prevention of atherosclerosis
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