Kidney transplantation in genetic (Factor H deficient) haemolitic-uremic syndrome (HUS)

Interpretation of kidney graft outcome in HUS is frequently hindered by heterogeneity of case-mix; epidemic, more than idiopathic, and some mutations in complement system, such as membrane cofactor protein (MCP), carry a favourable prognosis, when compared with the more severe forms of factor H and I deficiency. Relapse of basic disease is common, particularly when calcineurin inhibitors (CNI) are used; rescue by means of plasma therapy is seldom and temporarily successful. Here we report a case of transplantation in Factor H deficient HUS.