Several compounds were prepared by coupling one of the two moieties of cinnarizine (1) with one of the two moieties of WB 4101 (2). In addition, compounds were synthesized lacking the piperazine ring. Their activities as Calcium-antagonists were evaluated on the taenia coli of the guinea-pig. These new compounds show lower activities as Ca antagonists than Cinnarizine (1).
Synthesis and Pharmacological Evaluation of Some Analogues of the Ca-Antagonist Cinnarizine / Stelano, Corsano; Giovannella, Strappaghetti; Brasili, Livio. - In: ARCHIV DER PHARMAZIE. - ISSN 0365-6233. - STAMPA. - 321:(1988), pp. 171-174.
Synthesis and Pharmacological Evaluation of Some Analogues of the Ca-Antagonist Cinnarizine
BRASILI, Livio
1988
Abstract
Several compounds were prepared by coupling one of the two moieties of cinnarizine (1) with one of the two moieties of WB 4101 (2). In addition, compounds were synthesized lacking the piperazine ring. Their activities as Calcium-antagonists were evaluated on the taenia coli of the guinea-pig. These new compounds show lower activities as Ca antagonists than Cinnarizine (1).
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