The influence of polyamines (putrescine, spermidine and spermine) on heart contractility was studied using perfused rat ventricle strips (2 X 10 mm), electrically driven at 1 Hz. Putrescine (100 microM) caused a negative inotropic effect gradually increasing in intensity, whereas spermidine and spermine (10 and 100 microM) caused a sharp, positive inotropic effect, followed by a rapid and more marked fall. The possibility that these effects of polyamines on heart contractility may be due to their role in Ca++ fluxes and mobilization, and in membrane functions, is discussed.

Effect of polyamines on perfused rat heart contractility / Bazzani, Carla; Genedani, Susanna; Bertolini, Alfio. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - STAMPA. - 18:(1986), pp. 503-512.

Effect of polyamines on perfused rat heart contractility

BAZZANI, Carla;GENEDANI, Susanna;BERTOLINI, Alfio
1986

Abstract

The influence of polyamines (putrescine, spermidine and spermine) on heart contractility was studied using perfused rat ventricle strips (2 X 10 mm), electrically driven at 1 Hz. Putrescine (100 microM) caused a negative inotropic effect gradually increasing in intensity, whereas spermidine and spermine (10 and 100 microM) caused a sharp, positive inotropic effect, followed by a rapid and more marked fall. The possibility that these effects of polyamines on heart contractility may be due to their role in Ca++ fluxes and mobilization, and in membrane functions, is discussed.
1986
18
503
512
Effect of polyamines on perfused rat heart contractility / Bazzani, Carla; Genedani, Susanna; Bertolini, Alfio. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - STAMPA. - 18:(1986), pp. 503-512.
Bazzani, Carla; Genedani, Susanna; Bertolini, Alfio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/742905
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