in this study we provided evidence that during degenerative liver disease as hepatocellular carcinoma (HCC) the peripheral benzodiazepine receptor (PBR) binding sites increse drammatically. Extract of tomatoes, mentha piperita, lavadula officinalis, citrus aurantium and melissa officinalis after HPLC separation gave rise to a series of compounds able to inhibit the binding of [3H]PK 11195, a specific binding for PBRs to rat adrenal glands.
Peripheral benzodiazepine receptors in liver tumors and presence of thei ligands in vegetbale and officinal plants / Corsi, Lorenzo; Avallone, Rossella; I., Venturini; Zeneroli, Maria Luisa; H., Alho; Baraldi, Mario. - STAMPA. - 1 suppl.5:(1998), pp. 52-52. (Intervento presentato al convegno Fitoterapia tenutosi a Modena nel 21-24 ottobre 1998).
Peripheral benzodiazepine receptors in liver tumors and presence of thei ligands in vegetbale and officinal plants.
CORSI, Lorenzo;AVALLONE, Rossella;ZENEROLI, Maria Luisa;BARALDI, Mario
1998
Abstract
in this study we provided evidence that during degenerative liver disease as hepatocellular carcinoma (HCC) the peripheral benzodiazepine receptor (PBR) binding sites increse drammatically. Extract of tomatoes, mentha piperita, lavadula officinalis, citrus aurantium and melissa officinalis after HPLC separation gave rise to a series of compounds able to inhibit the binding of [3H]PK 11195, a specific binding for PBRs to rat adrenal glands.
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