The presence of specific receptors for benzodiazepines (BDZ) suggested that these recognition sites could subserve a physiological role in the regulation of anxiety and sleep only if stimulated by endoigenous ligands. A polypeptide nmed DBI could be one putative endogenous ligands with diazepma binding inhibitory properties and with anxiogenic activity. Clinical experiments were designed in order to study the levels of the endogenous BDZs and in particular the relationship between BDZs and DBI in control.
Endogenous benzodiazepines / Baraldi, Mario; Avallone, Rossella; Corsi, Lorenzo; I., Venturini; Zeneroli, Maria Luisa. - STAMPA. - 1:(1999), pp. 45-45. (Intervento presentato al convegno 20emes Journees Francaises de Pharmacovigilance tenutosi a Nantes nel 15-17 march 1999).
Endogenous benzodiazepines
BARALDI, Mario;AVALLONE, Rossella;CORSI, Lorenzo;ZENEROLI, Maria Luisa
1999
Abstract
The presence of specific receptors for benzodiazepines (BDZ) suggested that these recognition sites could subserve a physiological role in the regulation of anxiety and sleep only if stimulated by endoigenous ligands. A polypeptide nmed DBI could be one putative endogenous ligands with diazepma binding inhibitory properties and with anxiogenic activity. Clinical experiments were designed in order to study the levels of the endogenous BDZs and in particular the relationship between BDZs and DBI in control.
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