Gonadal steroids are believed to influence glucose metabolism, oestrogens inducing an improvement and androgens or progestins a deterioration. At baseline and after 3 months of ovarian suppression with a gonadotrophin-releasing hormone analogue (GnRHa: goserelin depot 3.75 mg/28 days), glucose metabolism was evaluated in eight lean women affected by ovarian hyperandrogenism (PCOS) and six age-weight-matched non-hyperandrogenic women (controls) by using both an oral glucose tolerance test (75 g; OGTT) and the minimal model method. The latter method allows calculation of peripheral insulin sensitivity (Si) and glucose dependent glucose utilization (Sg). In PCOS, higher fasting concentrations (P < 0.05) of insulin and C-peptide, and lower Sg (P < 0.05) and Si (P < 0.01) were found. GnRHa did not significantly modify glucose metabolism of controls, while in women with PCOS it decreased fasting glucose (P < 0.05) and significantly increased Si (P < 0.03) up to control values. The present data indicate that strong suppression of ovarian activity improves Si in lean women with PCOS, while it is without relevant effects on glucose metabolism of non-hyperandrogenic women.

Effect of ovarian suppression on glucose metabolism of young lean women with and without ovarian hyperandrogenism / Cagnacci, Angelo; A. M., Paoletti; S., Arangino; G. B., Melis; Volpe, Annibale. - In: HUMAN REPRODUCTION. - ISSN 0268-1161. - STAMPA. - 14:(1999), pp. 893-897.

Effect of ovarian suppression on glucose metabolism of young lean women with and without ovarian hyperandrogenism.

CAGNACCI, Angelo;VOLPE, Annibale
1999

Abstract

Gonadal steroids are believed to influence glucose metabolism, oestrogens inducing an improvement and androgens or progestins a deterioration. At baseline and after 3 months of ovarian suppression with a gonadotrophin-releasing hormone analogue (GnRHa: goserelin depot 3.75 mg/28 days), glucose metabolism was evaluated in eight lean women affected by ovarian hyperandrogenism (PCOS) and six age-weight-matched non-hyperandrogenic women (controls) by using both an oral glucose tolerance test (75 g; OGTT) and the minimal model method. The latter method allows calculation of peripheral insulin sensitivity (Si) and glucose dependent glucose utilization (Sg). In PCOS, higher fasting concentrations (P < 0.05) of insulin and C-peptide, and lower Sg (P < 0.05) and Si (P < 0.01) were found. GnRHa did not significantly modify glucose metabolism of controls, while in women with PCOS it decreased fasting glucose (P < 0.05) and significantly increased Si (P < 0.03) up to control values. The present data indicate that strong suppression of ovarian activity improves Si in lean women with PCOS, while it is without relevant effects on glucose metabolism of non-hyperandrogenic women.
1999
14
893
897
Effect of ovarian suppression on glucose metabolism of young lean women with and without ovarian hyperandrogenism / Cagnacci, Angelo; A. M., Paoletti; S., Arangino; G. B., Melis; Volpe, Annibale. - In: HUMAN REPRODUCTION. - ISSN 0268-1161. - STAMPA. - 14:(1999), pp. 893-897.
Cagnacci, Angelo; A. M., Paoletti; S., Arangino; G. B., Melis; Volpe, Annibale
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/740326
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