Cultures of limbal cells are a safe and effective treatmentfor the destruction of the human cornea owing to chemicalburns. The essential feature of the graft is the presenceof an adequate number of stem cells, which can bedetermined by the expression of the p63 transcriptionfactor. Here, we will discuss the general principles definingthe rigorous criteria for graftable limbal cultures inlight of their clinical performances. Such criteria mightprove relevant to the future therapeutic use of anycultured cell type.
Vision from the right stem. [5YIF: 9.93; Citations: 13] / Pellegrini, Graziella; P., Rama; DE LUCA, Michele. - In: TRENDS IN MOLECULAR MEDICINE. - ISSN 1471-4914. - STAMPA. - 17:(2011), pp. 1-7. [10.1016/j.molmed.2010.10.003]
Vision from the right stem. [5YIF: 9.93; Citations: 13]
PELLEGRINI, Graziella;DE LUCA, Michele
2011
Abstract
Cultures of limbal cells are a safe and effective treatmentfor the destruction of the human cornea owing to chemicalburns. The essential feature of the graft is the presenceof an adequate number of stem cells, which can bedetermined by the expression of the p63 transcriptionfactor. Here, we will discuss the general principles definingthe rigorous criteria for graftable limbal cultures inlight of their clinical performances. Such criteria mightprove relevant to the future therapeutic use of anycultured cell type.
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