(R)- and (S)-2-Pyrrolidinemethanesulfonic acid, 3a and 3b, were synthesized from the corresponding N-Boc-2-(hydroxymethyl)-1-pyrrolidine, 6a and 6b. This asymmetric synthesis proceeds in mild conditions, with good overall yields and high enantiomeric purities (>99% ee).
Asymmetric synthesis of (R)- and (S)-2-pyrrolidinemethanesulfonic acid / Braghiroli, Daniela; Avallone, Rossella; DI BELLA, Maria. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - STAMPA. - 8:(1997), pp. 2209-2213.
Asymmetric synthesis of (R)- and (S)-2-pyrrolidinemethanesulfonic acid
BRAGHIROLI, Daniela;AVALLONE, Rossella;DI BELLA, Maria
1997
Abstract
(R)- and (S)-2-Pyrrolidinemethanesulfonic acid, 3a and 3b, were synthesized from the corresponding N-Boc-2-(hydroxymethyl)-1-pyrrolidine, 6a and 6b. This asymmetric synthesis proceeds in mild conditions, with good overall yields and high enantiomeric purities (>99% ee).
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