The BMP signaling pathway controls a number of cell processes during development and in adult tissues. At the cellular level, ligands of the BMP family act by binding a hetero-tetrameric signaling complex, composed of two type I and two type If receptors. BMP ligands make use of a limited number of receptors, which in turn activate a common signal transduction cascade at the intracellular level. A complex regulatory network is required in order to activate the signaling cascade at proper times and locations, and to generate specific downstream effects in the appropriate cellular context.
The RGM/DRAGON family of BMP co-receptors / Corradini, Elena; Babitt, Jl; Lin, Hy. - In: CYTOKINE & GROWTH FACTOR REVIEWS. - ISSN 1359-6101. - STAMPA. - 20(5-6):(2009), pp. 389-398. [10.1016/j.cytogfr.2009.10.008]
The RGM/DRAGON family of BMP co-receptors.
CORRADINI, Elena;
2009
Abstract
The BMP signaling pathway controls a number of cell processes during development and in adult tissues. At the cellular level, ligands of the BMP family act by binding a hetero-tetrameric signaling complex, composed of two type I and two type If receptors. BMP ligands make use of a limited number of receptors, which in turn activate a common signal transduction cascade at the intracellular level. A complex regulatory network is required in order to activate the signaling cascade at proper times and locations, and to generate specific downstream effects in the appropriate cellular context.
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