The K72A/K73H/K79A mutant of yeast iso-1-cytochrome c immobilized on a conductive substrate reversibly interconverts between the native-like, His-Met heme-ligated form and a His-His-ligated conformer with remarkably different redox and enzymatic properties. This transition is activated by changing the pH in a narrow range around neutrality.
A surface-immobilized cytochrome c variant provides a pH-controlled molecular switch / Bortolotti, Carlo Augusto; Paltrinieri, Licia; Monari, Stefano; Ranieri, Antonio; Borsari, Marco; Battistuzzi, Gianantonio; Sola, Marco. - In: CHEMICAL SCIENCE. - ISSN 2041-6520. - STAMPA. - 3:(2012), pp. 807-810. [10.1039/c1sc00821h]
A surface-immobilized cytochrome c variant provides a pH-controlled molecular switch
BORTOLOTTI, Carlo Augusto;PALTRINIERI, LICIA;MONARI, Stefano;RANIERI, Antonio;BORSARI, Marco;BATTISTUZZI, Gianantonio;SOLA, Marco
2012
Abstract
The K72A/K73H/K79A mutant of yeast iso-1-cytochrome c immobilized on a conductive substrate reversibly interconverts between the native-like, His-Met heme-ligated form and a His-His-ligated conformer with remarkably different redox and enzymatic properties. This transition is activated by changing the pH in a narrow range around neutrality.
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