In the Chapter 35 of the book are reported observations of recent pubblications on the effect of ferutinin in preventing/recovering severe osteoporosis secondary to ovariectomy in rats. On the basis of the results so far obtained, the authors suggest to enumerate ferutinin among the osteoprotective substances. This fact acquires a more relevant importance in the light of recent tenable evidences reported from various authors concerning the absence of negative side effects by some phytoestrogens (particularly genistein, 8-prenylnaringenin, reveratrol and red clover extract) on the tropism of various organs commonly targeted by estrogens. In conclusion, the results reported not only provide evidence that ferutinin can significantly prevent/recover ovariectomy-induced bone loss in rats, but also that it could protect against the onset of uterus cancer. Although the putative undesired estrogenic-like side effects on uterus of such phytoestrogen have not yet been fully investigated, ferutinin could be an interesting safer alternative new candidate for HRT in treatment of post-menopausal symptoms, since it seems to protect from bone loss induced by ovariectomy (Palumbo et al., 2009; Ferretti et al., 2010) and in part to mime the ovarian endocrine function during menopause.

ROLE OF PHYTOESTROGEN FERUTININ IN PREVENTING/RECOVERING BONE LOSS: RESULTS FROM EXPERIMENTAL OVARIECTOMIZED RAT MODEL / Palumbo, Carla; Cavani, Francesco; Bertoni, Laura; Ferretti, Marzia. - ELETTRONICO. - (2012), pp. 711-732. [10.5772/28910]

ROLE OF PHYTOESTROGEN FERUTININ IN PREVENTING/RECOVERING BONE LOSS: RESULTS FROM EXPERIMENTAL OVARIECTOMIZED RAT MODEL

PALUMBO, Carla;CAVANI, Francesco;BERTONI, Laura;FERRETTI, Marzia
2012

Abstract

In the Chapter 35 of the book are reported observations of recent pubblications on the effect of ferutinin in preventing/recovering severe osteoporosis secondary to ovariectomy in rats. On the basis of the results so far obtained, the authors suggest to enumerate ferutinin among the osteoprotective substances. This fact acquires a more relevant importance in the light of recent tenable evidences reported from various authors concerning the absence of negative side effects by some phytoestrogens (particularly genistein, 8-prenylnaringenin, reveratrol and red clover extract) on the tropism of various organs commonly targeted by estrogens. In conclusion, the results reported not only provide evidence that ferutinin can significantly prevent/recover ovariectomy-induced bone loss in rats, but also that it could protect against the onset of uterus cancer. Although the putative undesired estrogenic-like side effects on uterus of such phytoestrogen have not yet been fully investigated, ferutinin could be an interesting safer alternative new candidate for HRT in treatment of post-menopausal symptoms, since it seems to protect from bone loss induced by ovariectomy (Palumbo et al., 2009; Ferretti et al., 2010) and in part to mime the ovarian endocrine function during menopause.
2012
Osteoporosis
9789535100263
Edidet by: Yannis Dionyssiotis.Publisher: InTech - Open Access Publisher
CROAZIA
ROLE OF PHYTOESTROGEN FERUTININ IN PREVENTING/RECOVERING BONE LOSS: RESULTS FROM EXPERIMENTAL OVARIECTOMIZED RAT MODEL / Palumbo, Carla; Cavani, Francesco; Bertoni, Laura; Ferretti, Marzia. - ELETTRONICO. - (2012), pp. 711-732. [10.5772/28910]
Palumbo, Carla; Cavani, Francesco; Bertoni, Laura; Ferretti, Marzia
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