IGF-1 decline has been related to age-dependent cognitive impairment and dementia. No study examined IGF-1 levels in subjects with a risk factor for brain damage such as hypertension. We investigated the relationship between IGF-1, cognitive functioning and neuroimaging in a sample of 75 hypertensive elderly subjects aged > 65. Cognitive performance were tested by mini mental state examination (MMSE), Cambridge cognitive examination (CAMDEX-R), and the frontal assessment battery (FAB). Among other indices, free IGF-1 in serum was assayed. The radial width of the temporal horn (rWTH) evaluates medial cerebral temporal lobe atrophy. Significant correlations between IGF-1 levels and both total and sub-domain scores of cognition were found. IGF-1 level was significantly lower in cognitively declined group. The lowest IGF-1-percentile subgroup was significantly cognitively impaired. A statistically non-significant, but lower IGF-1 level was found in the sub-sample with pathologically wider rWTH. Levels of IGF-1 below 79.4 mu g/I are associated with cognitive decline, whereas a level above 118 mu g/I seems to be a marker of normal cognitive performance. A decreasing of IGF-1 related to a widening of the rWTH suggests an involvement of this hormone in hippocampus atrophy.
INSULIN-LIKE GROWTH FACTOR-1 (IGF-1): RELATION WITH COGNITIVE FUNCTIONING AND NEUROIMAGING MARKER OF BRAIN DAMAGE IN A SAMPLE OF HYPERTENSIVE ELDERLY SUBJECTS / Angelini, Annapina; Bendini, Chiara; Neviani, Francesca; Bergamini, Lucia; Manni, Barbara; T., Trenti; R., Rovati; Neri, Mirco. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 49:(2009), pp. 5-12. [10.1016/j.archger.2009.09.006]
INSULIN-LIKE GROWTH FACTOR-1 (IGF-1): RELATION WITH COGNITIVE FUNCTIONING AND NEUROIMAGING MARKER OF BRAIN DAMAGE IN A SAMPLE OF HYPERTENSIVE ELDERLY SUBJECTS
ANGELINI, Annapina;BENDINI, Chiara;NEVIANI, Francesca;BERGAMINI, Lucia;MANNI, Barbara;NERI, Mirco
2009
Abstract
IGF-1 decline has been related to age-dependent cognitive impairment and dementia. No study examined IGF-1 levels in subjects with a risk factor for brain damage such as hypertension. We investigated the relationship between IGF-1, cognitive functioning and neuroimaging in a sample of 75 hypertensive elderly subjects aged > 65. Cognitive performance were tested by mini mental state examination (MMSE), Cambridge cognitive examination (CAMDEX-R), and the frontal assessment battery (FAB). Among other indices, free IGF-1 in serum was assayed. The radial width of the temporal horn (rWTH) evaluates medial cerebral temporal lobe atrophy. Significant correlations between IGF-1 levels and both total and sub-domain scores of cognition were found. IGF-1 level was significantly lower in cognitively declined group. The lowest IGF-1-percentile subgroup was significantly cognitively impaired. A statistically non-significant, but lower IGF-1 level was found in the sub-sample with pathologically wider rWTH. Levels of IGF-1 below 79.4 mu g/I are associated with cognitive decline, whereas a level above 118 mu g/I seems to be a marker of normal cognitive performance. A decreasing of IGF-1 related to a widening of the rWTH suggests an involvement of this hormone in hippocampus atrophy.
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