In five children affected by HBsAg positive chronic persistent hepatitis a treatment with Levamisole (LMS) modified several immunological parameters which had been found altered before treatment. In particular the percentage of E rosette forming cells increased while that of EAC decreased; B lymphocytes with SmIgG and the responsiveness to phytohaemagglutinin, which were significantly decreased and increased respectively, got normal values. Since the persistence of HBsAg was unaffected by LMS treatment and a light increase of transaminase serum levels (GPT and GOT) was observed during treatment, doubts are expressed about the opportunity of using LMS in children affected by such a form of hepatitis.
Chronic persistent HBsAg positive hepatitis in children. II. Effect of treatment with levamisole / Masi, M; Paolucci, Paolo; Timoncini, G; Fantini, Mp; Chiodo, F; Franceschi, C.. - In: BOLLETTINO DELL'ISTITUTO SIEROTERAPICO MILANESE. - ISSN 0021-2547. - STAMPA. - 57(4):(1978), pp. 471-476.
Chronic persistent HBsAg positive hepatitis in children. II. Effect of treatment with levamisole.
PAOLUCCI, Paolo;
1978
Abstract
In five children affected by HBsAg positive chronic persistent hepatitis a treatment with Levamisole (LMS) modified several immunological parameters which had been found altered before treatment. In particular the percentage of E rosette forming cells increased while that of EAC decreased; B lymphocytes with SmIgG and the responsiveness to phytohaemagglutinin, which were significantly decreased and increased respectively, got normal values. Since the persistence of HBsAg was unaffected by LMS treatment and a light increase of transaminase serum levels (GPT and GOT) was observed during treatment, doubts are expressed about the opportunity of using LMS in children affected by such a form of hepatitis.
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