We have carried out an in vitro study on the interactions of human macrophages (J111) with two different membranes made of collagen type I and II, isolated from horse tendon and from horse articular and trachea cartilagene in order to obtain data on their biocompatibility. We have described the morphology of cell seeded on collagen films, and we have evaluated their proliferation as well as cytokine production as indicator of macrophage activation. The inflammatory response may in fact induce the destruction of collagen membranes and may interfere with cell and tissue behaviour. Results might be relevant for in vivo application such ad “tissue engeneering” and /or specialized cells implantation.
BIOCOMPATIBILITY OF COLLAGEN MEMBRANES ASSESSED BY CULTURING HUMAN J111 MACROPHAGES CELLS / Aruta, CLAUDIA GAETANA; Croce, Maria Antonietta; Quaglino, Daniela; Guerra, Deanna; Tiozzo, Roberta. - In: MATERIALS. - ISSN 1996-1944. - ELETTRONICO. - 2:3(2009), pp. 945-957. [10.3390/ma2030945]
BIOCOMPATIBILITY OF COLLAGEN MEMBRANES ASSESSED BY CULTURING HUMAN J111 MACROPHAGES CELLS.
ARUTA, CLAUDIA GAETANA;CROCE, Maria Antonietta;QUAGLINO, Daniela;GUERRA, Deanna;TIOZZO, Roberta
2009
Abstract
We have carried out an in vitro study on the interactions of human macrophages (J111) with two different membranes made of collagen type I and II, isolated from horse tendon and from horse articular and trachea cartilagene in order to obtain data on their biocompatibility. We have described the morphology of cell seeded on collagen films, and we have evaluated their proliferation as well as cytokine production as indicator of macrophage activation. The inflammatory response may in fact induce the destruction of collagen membranes and may interfere with cell and tissue behaviour. Results might be relevant for in vivo application such ad “tissue engeneering” and /or specialized cells implantation.
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