We found that Clu is down regulated during cancer progression in humans and in the TRAMP model. We reasoned that Knock down of Clu ( CLU KO mice) in a suitable prostate cancer model would affect disease progression. After crossing Clu KO with TRAMP mice, we observed a higher cancer invasion spreading in many different body sites including kidney and liver. In situ neoplastic and metastatic lesions, all positive for SV40 antigen transgene, were also consistently Ki67- and NF-kB- positive in TRAMP CLU-/- if compared to TRAMP CLU+/+ mice. Interestingly and surprisingly CLU depletion causes tumurigenesis in female TRAMP mice, which are normally cancer free.
Effects of CLU knock down on prostate cancer progression in the TRAMP model / S., Davoli; Davalli, Pierpaola; O., Chayka; F., Rizzi; D., Pellacani; G., Fregni; Astancolle, Serenella; M., Fassan; Corti, Arnaldo; R., Baffa; A., Sala; S., Bettuzzi. - In: THE FEBS JOURNAL. - ISSN 1742-4658. - STAMPA. - 276:(2009), pp. 363-364. (Intervento presentato al convegno 34° FEBS Congress tenutosi a Praga nel 4-9-luglio 2009).
Effects of CLU knock down on prostate cancer progression in the TRAMP model.
DAVALLI, Pierpaola;ASTANCOLLE, Serenella;CORTI, Arnaldo;
2009
Abstract
We found that Clu is down regulated during cancer progression in humans and in the TRAMP model. We reasoned that Knock down of Clu ( CLU KO mice) in a suitable prostate cancer model would affect disease progression. After crossing Clu KO with TRAMP mice, we observed a higher cancer invasion spreading in many different body sites including kidney and liver. In situ neoplastic and metastatic lesions, all positive for SV40 antigen transgene, were also consistently Ki67- and NF-kB- positive in TRAMP CLU-/- if compared to TRAMP CLU+/+ mice. Interestingly and surprisingly CLU depletion causes tumurigenesis in female TRAMP mice, which are normally cancer free.
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