In about 50% of patients with liver cirrhosis, upper digestive bleeding is not due to oesaphageal varices rupture, but to a group of peculiar mucosal lesions usually referred as "congestive gastropathy" and "hepatogenic ulcer". The pathogenesis of such mucosal damage is still unclear: an important causative role is commonly thought to be played by portal hypertension, but the role of peptical pathway and of the mucosal barrier impairment must not be underscored as well. Aim of this study was to evaluate the effect of roxatidine in the long-term treatment of mucosal damage in 19 patients with liver cirrhosis. Patients showed a good tolerance and no side effects. The improvement of endoscopic pattern after a three months period of roxatidine therapy was statistically significant; moreover there was no occurrence of digestive bleeding. In conclusion, H2 antagonist may be considered as the drug of choice for the treatment of mucosal damage in patients with liver cirrhosis, for both its safety and effectiveness.

Roxatidine in the treatment of gastroduodenal mucosal lesions in hepatic cirrhosis / C., Sardini; Ventura, Paolo; G. L., Abbati; G., Rigo; G., Cioni; A., Cristani; E., Tincani; E., Ventura. - In: RECENTI PROGRESSI IN MEDICINA. - ISSN 0034-1193. - STAMPA. - 85:(1994), pp. 517-520.

Roxatidine in the treatment of gastroduodenal mucosal lesions in hepatic cirrhosis

VENTURA, Paolo;
1994

Abstract

In about 50% of patients with liver cirrhosis, upper digestive bleeding is not due to oesaphageal varices rupture, but to a group of peculiar mucosal lesions usually referred as "congestive gastropathy" and "hepatogenic ulcer". The pathogenesis of such mucosal damage is still unclear: an important causative role is commonly thought to be played by portal hypertension, but the role of peptical pathway and of the mucosal barrier impairment must not be underscored as well. Aim of this study was to evaluate the effect of roxatidine in the long-term treatment of mucosal damage in 19 patients with liver cirrhosis. Patients showed a good tolerance and no side effects. The improvement of endoscopic pattern after a three months period of roxatidine therapy was statistically significant; moreover there was no occurrence of digestive bleeding. In conclusion, H2 antagonist may be considered as the drug of choice for the treatment of mucosal damage in patients with liver cirrhosis, for both its safety and effectiveness.
1994
85
517
520
Roxatidine in the treatment of gastroduodenal mucosal lesions in hepatic cirrhosis / C., Sardini; Ventura, Paolo; G. L., Abbati; G., Rigo; G., Cioni; A., Cristani; E., Tincani; E., Ventura. - In: RECENTI PROGRESSI IN MEDICINA. - ISSN 0034-1193. - STAMPA. - 85:(1994), pp. 517-520.
C., Sardini; Ventura, Paolo; G. L., Abbati; G., Rigo; G., Cioni; A., Cristani; E., Tincani; E., Ventura
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/617099
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