Hepatocellular carcinoma (HCC) remains one of the most common neoplasms in the world. Doxifluridine is an oral fluoropyrimidine derivative activated to 5-fluorouracil by uridine phosphorylase which is more expressed in malignant cells. Therefore, we conducted a phase II study to evaluate the activity of oral doxifluridine in patients with advanced hepatocellular carcinoma. Twenty-five advanced hepatocellular carcinoma patients entered the study; doxifluridine was given orally at the initial daily total dose of 2,250 mg for 4 consecutive days every week. All patients are evaluable for toxicity: these included mainly grade 1-2 (WHO) diarrhea, stomatitis, nausea and vomiting; 4 patients (16%) experienced grade 3-4 diarrhea. Twenty-four patients are evaluable for response and 1 complete and 3 partial responses have been observed (response rat 17%, 95% confidence interval: 5-37). Oral doxifluridine at the dose and schedule we used, although having only modest activity in advanced HCC, may represent an alternative to other frequently used chemotherapeutic agents, because of its favorable toxicity profile and its simple route of administration. Copyright 2000 S. Karger AG, Basel.

Oral doxifluridine in advanced hepatocellular carcinoma: A phase II study / M., Lencioni; A., Falcone; G., Allegrini; E., Pfanner; G., Masi; I., Brunetti; R., Di Marsico; E., Fontana; C., Orlandini; C., Gallo Stampino; C., Bartolozzi; Conte, Pierfranco. - In: ONCOLOGY. - ISSN 0030-2414. - STAMPA. - 59:3(2000), pp. 204-209. [10.1159/000012162]

Oral doxifluridine in advanced hepatocellular carcinoma: A phase II study

CONTE, Pierfranco
2000

Abstract

Hepatocellular carcinoma (HCC) remains one of the most common neoplasms in the world. Doxifluridine is an oral fluoropyrimidine derivative activated to 5-fluorouracil by uridine phosphorylase which is more expressed in malignant cells. Therefore, we conducted a phase II study to evaluate the activity of oral doxifluridine in patients with advanced hepatocellular carcinoma. Twenty-five advanced hepatocellular carcinoma patients entered the study; doxifluridine was given orally at the initial daily total dose of 2,250 mg for 4 consecutive days every week. All patients are evaluable for toxicity: these included mainly grade 1-2 (WHO) diarrhea, stomatitis, nausea and vomiting; 4 patients (16%) experienced grade 3-4 diarrhea. Twenty-four patients are evaluable for response and 1 complete and 3 partial responses have been observed (response rat 17%, 95% confidence interval: 5-37). Oral doxifluridine at the dose and schedule we used, although having only modest activity in advanced HCC, may represent an alternative to other frequently used chemotherapeutic agents, because of its favorable toxicity profile and its simple route of administration. Copyright 2000 S. Karger AG, Basel.
2000
59
3
204
209
Oral doxifluridine in advanced hepatocellular carcinoma: A phase II study / M., Lencioni; A., Falcone; G., Allegrini; E., Pfanner; G., Masi; I., Brunetti; R., Di Marsico; E., Fontana; C., Orlandini; C., Gallo Stampino; C., Bartolozzi; Conte, Pierfranco. - In: ONCOLOGY. - ISSN 0030-2414. - STAMPA. - 59:3(2000), pp. 204-209. [10.1159/000012162]
M., Lencioni; A., Falcone; G., Allegrini; E., Pfanner; G., Masi; I., Brunetti; R., Di Marsico; E., Fontana; C., Orlandini; C., Gallo Stampino; C., Bartolozzi; Conte, Pierfranco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/615540
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