1. The lysine salt of acetyl salicylic acid (ASA) at a dose equivalent to 400 mg/kg of acetyl salicylic acid (ASA) was intraperitoneally administered in rats. 2. After 30 and 120 min ASA did not modify the number of receptors nor the affinity of [H-3] 8-OH-DPAT binding sites in pens and cerebral cortex. On the other hand, the receptor number in the cortex membranes decreased significantly using [H-3] ketanserin as ligand, while the receptor number in the pontine membranes did not change. 3. These data support the involvement of central 5-HT receptors in the mode of action of ASA.
EFFECTS OF ACETYLSALICYCLIC ACID ON SEROTONIN BRAIN RECEPTOR SUBTYPES / Sandrini, Maurizio; Vitale, Giovanni; M., Dondi; Pini, Luigi Alberto. - In: GENERAL PHARMACOLOGY. - ISSN 0306-3623. - STAMPA. - 26(4):(1995), pp. 737-741.
EFFECTS OF ACETYLSALICYCLIC ACID ON SEROTONIN BRAIN RECEPTOR SUBTYPES
SANDRINI, Maurizio;VITALE, Giovanni;PINI, Luigi Alberto
1995
Abstract
1. The lysine salt of acetyl salicylic acid (ASA) at a dose equivalent to 400 mg/kg of acetyl salicylic acid (ASA) was intraperitoneally administered in rats. 2. After 30 and 120 min ASA did not modify the number of receptors nor the affinity of [H-3] 8-OH-DPAT binding sites in pens and cerebral cortex. On the other hand, the receptor number in the cortex membranes decreased significantly using [H-3] ketanserin as ligand, while the receptor number in the pontine membranes did not change. 3. These data support the involvement of central 5-HT receptors in the mode of action of ASA.
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