The first total synthesis of (8Z,13Z)-pentadeca-8,13-dien-11-yn-2-one is described. This dienynone was recently isolated from the n-hexane extract of Echinacea pallida roots and displayed a selective cytotoxic activity toward cancer cells, thus featuring as a potential anticancer lead. The product was obtained in 11 steps in 25% overall yield.
Total synthesis of a dienynone from Echinacea pallida / S., Morandi; Pellati, Federica; Benvenuti, Stefania; Prati, Fabio. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 64:(2008), pp. 6324-6328. [10.1016/j.tet.2008.04.094]
Total synthesis of a dienynone from Echinacea pallida
PELLATI, Federica;BENVENUTI, Stefania;PRATI, Fabio
2008
Abstract
The first total synthesis of (8Z,13Z)-pentadeca-8,13-dien-11-yn-2-one is described. This dienynone was recently isolated from the n-hexane extract of Echinacea pallida roots and displayed a selective cytotoxic activity toward cancer cells, thus featuring as a potential anticancer lead. The product was obtained in 11 steps in 25% overall yield.
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