An integrated field-effect device for fully electronic deoxyribonucleic acid (DNA) detection was realized in a standard CMOS process. The device is composed of a floating-gate MOS transistor, a control-capacitor acting as integrated counterelectrode, and an exposed active area for DNA immobilization. The drain-current of the transistor is modulated by the electric charge carried by the DNA molecules. After DNA hybridization, this charge increases and a change in the output current is measured. Experimental results are provided. Full compatibility with a standard CMOS process-opens the way to the realization of low-cost large-scale integration of fast electronic DNA detectors.

A CMOS, fully integrated sensor for electronic detection of DNA hybridization / M., Barbaro; A., Bonfiglio; L., Raffo; Alessandrini, Andrea; P., Facci; I., Barak. - In: IEEE ELECTRON DEVICE LETTERS. - ISSN 0741-3106. - STAMPA. - 27:7(2006), pp. 595-597. [10.1109/LED.2006.876303]

A CMOS, fully integrated sensor for electronic detection of DNA hybridization

ALESSANDRINI, Andrea;
2006

Abstract

An integrated field-effect device for fully electronic deoxyribonucleic acid (DNA) detection was realized in a standard CMOS process. The device is composed of a floating-gate MOS transistor, a control-capacitor acting as integrated counterelectrode, and an exposed active area for DNA immobilization. The drain-current of the transistor is modulated by the electric charge carried by the DNA molecules. After DNA hybridization, this charge increases and a change in the output current is measured. Experimental results are provided. Full compatibility with a standard CMOS process-opens the way to the realization of low-cost large-scale integration of fast electronic DNA detectors.
2006
27
7
595
597
A CMOS, fully integrated sensor for electronic detection of DNA hybridization / M., Barbaro; A., Bonfiglio; L., Raffo; Alessandrini, Andrea; P., Facci; I., Barak. - In: IEEE ELECTRON DEVICE LETTERS. - ISSN 0741-3106. - STAMPA. - 27:7(2006), pp. 595-597. [10.1109/LED.2006.876303]
M., Barbaro; A., Bonfiglio; L., Raffo; Alessandrini, Andrea; P., Facci; I., Barak
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/613142
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