Objective: Large cell neuroendocrine carcinoma of the lung are considered aggressive. However, reported prognoses are heterogeneous and the optimum treatment remains undefined. We retrospectively evaluated outcomes in a series of patients with a pathological diagnosis of Large cell. neuroendocrine lung carcinoma, who underwent lung resection. We also assessed the utility of chemotherapy in a small subgroup. Patients and methods: The clinical records of 144 consecutive patients were reviewed in a multicenter study. Survival times, assessed from the day of surgery until death or most recent follow-up, were estimated by the Kaplan-Meier method, and compared by the log rank test. Results: There were 117 men and 27 women of median age 63 years. Twelve wedge resections, 3 segmentectomies, 95 lobectomies, 7 bilobectomies and 24 pneumonectomies were performed. Induction chemotherapy was given in 21 and postoperative chemotherapy in 24. Pathologically, 73 (50%) were stage I, 29 (20%) stage II, 40 (28%) stage III and 2 stage IV. Postoperative mortality was 2.8% and morbidity 26%. Overall. 5-year survival was 42.5%: 52% for stage I, 59% for stage II and 20% for stage III (p = 0.001 log-rank test on Kaplan-Meier curves). A trend to better outcome was associated with preoperative or postoperative chemotherapy in stage I disease (p = 0.077) compared to no chemotherapy. The response rate to induction chemotherapy was 80% in the 15 patients with data available. Conclusion: large cell neuroendocrine carcinoma of the lung are confirmed as aggressive but are also chemosensitive. Our experience suggests that chemotherapy may improve prognosis in stage I disease.
|Data di pubblicazione:||2006|
|Titolo:||Large cell neuroendocrine carcinoma of the lung: A retrospective analysis of 144 surgical cases|
|Autore/i:||Veronesi, G; Morandi, Uliano; Alloisio, M; Terzi, A; Cardillo, G; Filosso, P; Rea, F; Facciolo, F; Pelosi, G; Gandini, S; Calabro, F; Casali, C; Marulli, G; Spaggiari, L.|
|Digital Object Identifier (DOI):||10.1016/j.lungcan.2006.03.007|
|Codice identificativo ISI:||WOS:000238713400015|
|Codice identificativo Scopus:||2-s2.0-33744795445|
|Codice identificativo Pubmed:||16697073|
|Citazione:||Large cell neuroendocrine carcinoma of the lung: A retrospective analysis of 144 surgical cases / Veronesi, G; Morandi, Uliano; Alloisio, M; Terzi, A; Cardillo, G; Filosso, P; Rea, F; Facciolo, F; Pelosi, G; Gandini, S; Calabro, F; Casali, C; Marulli, G; Spaggiari, L.. - In: LUNG CANCER. - ISSN 0169-5002. - STAMPA. - 53(2006), pp. 111-115.|
|Tipologia||Articolo su rivista|
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