We studied 36 male rats, 18 o them were trated orally for 30 days with 60 mg/kg/day of phenazone and 18 used as controls. Our data show that a chronic treatment with phenazone increases the number of serotonin receptors in two brain areas while the affinity is not modified; in the same model we demonstrated that phenzone modifies noradrenergic pontine receptors. The role of these changes in receptors characterstics after a long-term treatment with phenazone may contribute to the antinociceptive effect of phenazone.
The effect of chronic treatment with phenazone on [3H]-serotonin binding sites in pons and cortex membranes of the rat / Vitale, Giovanni; Pini, Luigi Alberto; Sandrini, Maurizio. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 25(S1):(1992), pp. 53-54.
The effect of chronic treatment with phenazone on [3H]-serotonin binding sites in pons and cortex membranes of the rat
VITALE, Giovanni;PINI, Luigi Alberto;SANDRINI, Maurizio
1992
Abstract
We studied 36 male rats, 18 o them were trated orally for 30 days with 60 mg/kg/day of phenazone and 18 used as controls. Our data show that a chronic treatment with phenazone increases the number of serotonin receptors in two brain areas while the affinity is not modified; in the same model we demonstrated that phenzone modifies noradrenergic pontine receptors. The role of these changes in receptors characterstics after a long-term treatment with phenazone may contribute to the antinociceptive effect of phenazone.
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