In leukemic cells, glucose transport is activated by SCF and H2O2 through a common signal cascade involving Akt, PLC gamma, Syk, and the Src family, in this order. An explanation can be provided by the phosphorylation of c-kit, the SCF receptor, elicited by either SCF or H2O2. Moreover, antioxidants prevent the SCF effect on glucose transport, confirming the involvement of H2O2 in the pathway leading to glucose-transport activation and suggesting a potential role for reactive oxygen species in leukemia proliferation.
Glucose-transport regulation in leukemic cells: how can H2O2 mimic stem cell factor effects? / Maraldi, Tullia; Diana, Fiorentini; Cecilia, Prata; Laura, Landi; Gabriele, Hakim. - In: ANTIOXIDANTS & REDOX SIGNALING. - ISSN 1523-0864. - STAMPA. - 9:2(2007), pp. 271-279. [10.1089/ars.2007.9.271]
Glucose-transport regulation in leukemic cells: how can H2O2 mimic stem cell factor effects?
MARALDI, Tullia;
2007
Abstract
In leukemic cells, glucose transport is activated by SCF and H2O2 through a common signal cascade involving Akt, PLC gamma, Syk, and the Src family, in this order. An explanation can be provided by the phosphorylation of c-kit, the SCF receptor, elicited by either SCF or H2O2. Moreover, antioxidants prevent the SCF effect on glucose transport, confirming the involvement of H2O2 in the pathway leading to glucose-transport activation and suggesting a potential role for reactive oxygen species in leukemia proliferation.
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