Apoptosis and necrosis coexist in ischemia-reperfusion (I/R) injury following organ transplant. During experimental liver transplant we evidenced a deep alteration in energy and antioxidant status. The activity of purine catabolic enzymes was also altered. Caspase-3 (C-3), protein tyrosine phosphatase (PTP) showed significative alterations that lead to DNA fragmentation. These findings could be of interest in new potential strategy to prevent and treat I/R injury.
LIVER TRANSPLANT: ADENOSINE METABOLISM AND APOPTOSIS / Carlucci, F; Marinell, E; Gerunda, Giorgio Enrico; Neri, D; Rosi, F; Floccari, F; Tabucchi, A.. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - 23:8-9(2004), pp. 1295-1299. [10.1081/NCN-200027551]
LIVER TRANSPLANT: ADENOSINE METABOLISM AND APOPTOSIS
GERUNDA, Giorgio Enrico;
2004
Abstract
Apoptosis and necrosis coexist in ischemia-reperfusion (I/R) injury following organ transplant. During experimental liver transplant we evidenced a deep alteration in energy and antioxidant status. The activity of purine catabolic enzymes was also altered. Caspase-3 (C-3), protein tyrosine phosphatase (PTP) showed significative alterations that lead to DNA fragmentation. These findings could be of interest in new potential strategy to prevent and treat I/R injury.
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