A number of flavone and xanthone derivatives bearing some characteristic features of fluoroquinolones such as the fluorine atom and an ortho piperazine ring are described. The new compounds have been tested for possible cytotoxic and antimicrobial activities. Cytotoxicity of both groups of compounds is rather poor, while the antibacterial activity is restricted to xanthones.
Flavone and Xanthone derivatives related to fluoroquinolones / S., Mari; Rossi, Maddalena; P., Valenti; P., DA RE. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 54:(1999), pp. 411-415.
Flavone and Xanthone derivatives related to fluoroquinolones
ROSSI, Maddalena;
1999
Abstract
A number of flavone and xanthone derivatives bearing some characteristic features of fluoroquinolones such as the fluorine atom and an ortho piperazine ring are described. The new compounds have been tested for possible cytotoxic and antimicrobial activities. Cytotoxicity of both groups of compounds is rather poor, while the antibacterial activity is restricted to xanthones.
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