Wilms' tumor gene (WT1) can play significant roles both as a tumor suppressor gene and oncogene. The role of tumor suppressor gene can be supported by the finding of leukemic cells showing WT1 mutation, as well as high levels of WT1 RNA were expressed by the 48% of patients, with a negative impact on the clinical outcome.
Vorinostat and bortezomib significantly inhibit WT1 gene expression in MO7-e and P39 cell lines / Galimberti, S; Canestraro, M; Khan, R; Buda, G; Orciuolo, E; Guerrini, F; Fazzi, R; Maffei, Rossana; Marasca, Roberto; Petrini, M.. - In: LEUKEMIA. - ISSN 0887-6924. - STAMPA. - 22:(2008), pp. 628-631. [10.1038/sj.leu.2404918]
Vorinostat and bortezomib significantly inhibit WT1 gene expression in MO7-e and P39 cell lines
MAFFEI, Rossana;MARASCA, Roberto;
2008
Abstract
Wilms' tumor gene (WT1) can play significant roles both as a tumor suppressor gene and oncogene. The role of tumor suppressor gene can be supported by the finding of leukemic cells showing WT1 mutation, as well as high levels of WT1 RNA were expressed by the 48% of patients, with a negative impact on the clinical outcome.
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