The efficacy of growth hormone (GH) therapy in short normal children (i.e. children without classical growth hormone deficiency [GHD]) is still under debate. This paper presents the preliminary data of a retrospective Italian multicenter study on children treated with GH until adult height was reached. Final adult height (FAH), however, is not significantly different from the predicted adult height (PAH) calculated at the beginning of treatment. This result is in agreement with those reported in the majority of other similar international surveys. In conclusion, GH should be administered to short normal children only within the framework of well designed prospective experimental studies, which should consider several auxological, clinical and biochemical parameters capable of influencing the therapeutic results.
GROWTH HORMONE TREATMENT IN SHORT NORMAL CHILDREN / S., Bernasconi; C., Volta; M. E., Street; G., Mazzardo; A., Ferzetti; Iughetti, Lorenzo; L., Ghizzoni. - In: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM. - ISSN 0334-018X. - STAMPA. - 9:(1996), pp. 339-343. (Intervento presentato al convegno International Novo Nordisk Symposium on Growth tenutosi a SANTIAGO COMPOSTE, SPAIN nel OCT, 1995).
GROWTH HORMONE TREATMENT IN SHORT NORMAL CHILDREN
IUGHETTI, Lorenzo;
1996
Abstract
The efficacy of growth hormone (GH) therapy in short normal children (i.e. children without classical growth hormone deficiency [GHD]) is still under debate. This paper presents the preliminary data of a retrospective Italian multicenter study on children treated with GH until adult height was reached. Final adult height (FAH), however, is not significantly different from the predicted adult height (PAH) calculated at the beginning of treatment. This result is in agreement with those reported in the majority of other similar international surveys. In conclusion, GH should be administered to short normal children only within the framework of well designed prospective experimental studies, which should consider several auxological, clinical and biochemical parameters capable of influencing the therapeutic results.
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