Several aberrant chromosomal constellations are known in men. Of these the karyotype XXY (Klinefelter syndrome, KS) is the most common chromosomal disorder with a prevalence of about one in 800 live-born boys. KS is associated with hypogonadism and is suspected to cause variable physical, physiological and cognitive abnormalities. As a supernumerary X chromosome is also associated with infertility, sound animal models for KS are difficult to obtain. In this study, male mice with two X chromosomes (XXYlow asterisk) were derived from fathers carrying a structurally rearranged Y chromosome (Ylow asterisk) that resulted in physical attachment of a part of the Y chromosome to one X. These animals display certain physiological features that resemble closely those of human KS and can also be utilized to study X chromosomal imbalance and cognition. Therefore 15 XXYlow asterisk males and 15 XYlow asterisk controls were subjected to a battery of behavioral tests, including a general health check, analysis of spontaneous exploration and locomotor activity, measures for anxiety-related behavior and the “novel object task” to test memory performance. Physiologically, XYlow asterisk males did not differ from C57Bl/6 wild type mice carrying a normal Y chromosome, which provided a valid control group. All mice appeared healthy. XXYlow asterisk mice did not differ from their wild type littermates with respect to locomotion, exploration and anxiety-related behavior. XXYlow asterisk male mice, however, exhibited no significant recognition memory performance in contrast with wild type XYlow asterisk males that readily fulfilled a given task. These findings support the hypothesis that the presence of a supernumerary X in male mice influences cognitive abilities. We suggest that the altered endocrine state and/or changes in the dosage of X-linked genes in the XXYlow asterisk mouse model affect brain function, in particular those regions responsible for cognition and learning behavior.

Impaired recognition memory in male mice with a supernumerary X chromosome / Lewejohann, L; Damm, O; Luetjens, M; Hämäläinen, ; Simoni, Manuela; Nieschlag, E; Gromoll, J; Wistuba, J.. - In: PHYSIOLOGY & BEHAVIOR. - ISSN 0031-9384. - ELETTRONICO. - 96:(2009), pp. 23-29. [10.1016/j.physbeh.2008.08.007]

Impaired recognition memory in male mice with a supernumerary X chromosome.

SIMONI, Manuela;
2009

Abstract

Several aberrant chromosomal constellations are known in men. Of these the karyotype XXY (Klinefelter syndrome, KS) is the most common chromosomal disorder with a prevalence of about one in 800 live-born boys. KS is associated with hypogonadism and is suspected to cause variable physical, physiological and cognitive abnormalities. As a supernumerary X chromosome is also associated with infertility, sound animal models for KS are difficult to obtain. In this study, male mice with two X chromosomes (XXYlow asterisk) were derived from fathers carrying a structurally rearranged Y chromosome (Ylow asterisk) that resulted in physical attachment of a part of the Y chromosome to one X. These animals display certain physiological features that resemble closely those of human KS and can also be utilized to study X chromosomal imbalance and cognition. Therefore 15 XXYlow asterisk males and 15 XYlow asterisk controls were subjected to a battery of behavioral tests, including a general health check, analysis of spontaneous exploration and locomotor activity, measures for anxiety-related behavior and the “novel object task” to test memory performance. Physiologically, XYlow asterisk males did not differ from C57Bl/6 wild type mice carrying a normal Y chromosome, which provided a valid control group. All mice appeared healthy. XXYlow asterisk mice did not differ from their wild type littermates with respect to locomotion, exploration and anxiety-related behavior. XXYlow asterisk male mice, however, exhibited no significant recognition memory performance in contrast with wild type XYlow asterisk males that readily fulfilled a given task. These findings support the hypothesis that the presence of a supernumerary X in male mice influences cognitive abilities. We suggest that the altered endocrine state and/or changes in the dosage of X-linked genes in the XXYlow asterisk mouse model affect brain function, in particular those regions responsible for cognition and learning behavior.
2009
96
23
29
Impaired recognition memory in male mice with a supernumerary X chromosome / Lewejohann, L; Damm, O; Luetjens, M; Hämäläinen, ; Simoni, Manuela; Nieschlag, E; Gromoll, J; Wistuba, J.. - In: PHYSIOLOGY & BEHAVIOR. - ISSN 0031-9384. - ELETTRONICO. - 96:(2009), pp. 23-29. [10.1016/j.physbeh.2008.08.007]
Lewejohann, L; Damm, O; Luetjens, M; Hämäläinen, ; Simoni, Manuela; Nieschlag, E; Gromoll, J; Wistuba, J.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/607442
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