Background-To establish whether transsulfuration impairment (methionine intolerance) may influence total plasma homocysteine (Hcy) in response to insulin infusion in type II diabetic patients (DB).Materials and Methods- DB with normal (group A, n=13) and abnormal (hyperhomocysteinemia, HHcy)) (Group B, n=17) response to oral methionine load underwent a glucose/clamp study. At time 0, and 30, 60 and 120 minutes after hyperinsulinemia, Hcy and methionine (Met) plasma levels were assessed. All patients were assayed for fasting Homocysteine-Cysteine ratio (as marker of suspected heterozygosis for cystathionine--synthase deficit) and vitamin status [serum vitamin B6 (PLP), vitamin B12 and folate]. Results- After hyperinsulinemia, plasma methionine reduced (about –30% at 120 minutes vs. basal values) within both groups, whereas Hcy decreased in group A (up to –15.2  8.9 % at 120 minutes) and increased in group B (up to +30.6  10.9 % at 120 minutes). (see figure) PLP was higher in group A than in group B (94.2  42.6 vs. 54.6  32.4 nmol/L; p<0.01); group A showed a lower prevalence of suspected heterozygosis for cystathionine--synthase deficit (1/13 (7,7%) vs.13/17 (76.5%), p=0.000). Conclusions-Methionine intolerance may influence insulin effect on plasma Hcy. To prevent a possible acute HHcy due to insulin administration in case of transsulfuration impairment, it may be suggested to assess transsulfuration capacity in all patients due to be subjected to insulin therapy.

Methionine intolerance and plasma homocysteine after insulin infusion in type II diabetic patients / Ventura, Paolo; Panini, Rossana; S., Emiliani; Salvioli, Gianfranco. - STAMPA. - 1:(2001), pp. 204-204. (Intervento presentato al convegno Homocysteine Metabolism 3rd International Conference tenutosi a Sorrento - Italy nel 1-5 July 2001).

Methionine intolerance and plasma homocysteine after insulin infusion in type II diabetic patients

VENTURA, Paolo;PANINI, Rossana;SALVIOLI, Gianfranco
2001

Abstract

Background-To establish whether transsulfuration impairment (methionine intolerance) may influence total plasma homocysteine (Hcy) in response to insulin infusion in type II diabetic patients (DB).Materials and Methods- DB with normal (group A, n=13) and abnormal (hyperhomocysteinemia, HHcy)) (Group B, n=17) response to oral methionine load underwent a glucose/clamp study. At time 0, and 30, 60 and 120 minutes after hyperinsulinemia, Hcy and methionine (Met) plasma levels were assessed. All patients were assayed for fasting Homocysteine-Cysteine ratio (as marker of suspected heterozygosis for cystathionine--synthase deficit) and vitamin status [serum vitamin B6 (PLP), vitamin B12 and folate]. Results- After hyperinsulinemia, plasma methionine reduced (about –30% at 120 minutes vs. basal values) within both groups, whereas Hcy decreased in group A (up to –15.2  8.9 % at 120 minutes) and increased in group B (up to +30.6  10.9 % at 120 minutes). (see figure) PLP was higher in group A than in group B (94.2  42.6 vs. 54.6  32.4 nmol/L; p<0.01); group A showed a lower prevalence of suspected heterozygosis for cystathionine--synthase deficit (1/13 (7,7%) vs.13/17 (76.5%), p=0.000). Conclusions-Methionine intolerance may influence insulin effect on plasma Hcy. To prevent a possible acute HHcy due to insulin administration in case of transsulfuration impairment, it may be suggested to assess transsulfuration capacity in all patients due to be subjected to insulin therapy.
2001
Homocysteine Metabolism 3rd International Conference
Sorrento - Italy
1-5 July 2001
Ventura, Paolo; Panini, Rossana; S., Emiliani; Salvioli, Gianfranco
Methionine intolerance and plasma homocysteine after insulin infusion in type II diabetic patients / Ventura, Paolo; Panini, Rossana; S., Emiliani; Salvioli, Gianfranco. - STAMPA. - 1:(2001), pp. 204-204. (Intervento presentato al convegno Homocysteine Metabolism 3rd International Conference tenutosi a Sorrento - Italy nel 1-5 July 2001).
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