A translucent coat of calcium alginate with a wrinkled appearance was obtained around the PVA matrices. Increase in coating time led to an increase in the coat thickness and a decrease in drug content, also, a certain amount of drug appeared in the coat.The drug release was affected by the thickness and the pH-dependent behaviour of the coat. In fact, the drug was released from the swollen matrix through the intact coat in simulated gastric fluid and through the gelatinized coat in simulated intestinal fluid giving linear profiles, after a burst effect.
Calcium alginate membrane coated matrices as oral drug delivery system / Coppi, Gilberto; Iannuccelli, Valentina; Cameroni, Riccardo. - STAMPA. - 46:(1995), pp. 283-283. (Intervento presentato al convegno 1st Central European Symposium on Pharmaceutical Technology tenutosi a Bled - Slovenia nel 19-20 ottobre 1995).
Calcium alginate membrane coated matrices as oral drug delivery system
COPPI, Gilberto;IANNUCCELLI, Valentina;CAMERONI, Riccardo
1995
Abstract
A translucent coat of calcium alginate with a wrinkled appearance was obtained around the PVA matrices. Increase in coating time led to an increase in the coat thickness and a decrease in drug content, also, a certain amount of drug appeared in the coat.The drug release was affected by the thickness and the pH-dependent behaviour of the coat. In fact, the drug was released from the swollen matrix through the intact coat in simulated gastric fluid and through the gelatinized coat in simulated intestinal fluid giving linear profiles, after a burst effect.
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