The interaction of nano-particles derived from ceramic objects and handicrafts with the human body has been investigated with a particular emphasis to defense mechanisms. Macrophage (professional) and epithelial (non-professional) cells were exposed in vitro to TiO2, SiO2, or ZrO2 nano-particles, and their vitality and inflammatory/immune activation checked. All nano-particles showed effects on cell activation, although different in nature and extent. In particular, SiO2 nano-particles directly induced significant inflammatory activation of macrophages, as judged by production of the inflammatory cytokines IL-1beta and TNF-alpha and TLR modulation. Thus, it is suggested that exposure to ceramic nano-particles can contribute to the induction of inflammation-related pathologies.

Modulation of defense cell functions by nano-particles in vitro / Lucarelli, M; Monari, Emanuela; Gatti, Antonietta; Boraschi, D.. - STAMPA. - 254-2:(2004), pp. 907-910. (Intervento presentato al convegno 16th International Symposium on Ceramics in Medicine tenutosi a Oporto, PORTUGAL nel NOV 06-09, 2003) [10.4028/www.scientific.net/KEM.254-256.907].

Modulation of defense cell functions by nano-particles in vitro

MONARI, Emanuela;GATTI, Antonietta;
2004

Abstract

The interaction of nano-particles derived from ceramic objects and handicrafts with the human body has been investigated with a particular emphasis to defense mechanisms. Macrophage (professional) and epithelial (non-professional) cells were exposed in vitro to TiO2, SiO2, or ZrO2 nano-particles, and their vitality and inflammatory/immune activation checked. All nano-particles showed effects on cell activation, although different in nature and extent. In particular, SiO2 nano-particles directly induced significant inflammatory activation of macrophages, as judged by production of the inflammatory cytokines IL-1beta and TNF-alpha and TLR modulation. Thus, it is suggested that exposure to ceramic nano-particles can contribute to the induction of inflammation-related pathologies.
2004
16th International Symposium on Ceramics in Medicine
Oporto, PORTUGAL
NOV 06-09, 2003
254-2
907
910
Lucarelli, M; Monari, Emanuela; Gatti, Antonietta; Boraschi, D.
Modulation of defense cell functions by nano-particles in vitro / Lucarelli, M; Monari, Emanuela; Gatti, Antonietta; Boraschi, D.. - STAMPA. - 254-2:(2004), pp. 907-910. (Intervento presentato al convegno 16th International Symposium on Ceramics in Medicine tenutosi a Oporto, PORTUGAL nel NOV 06-09, 2003) [10.4028/www.scientific.net/KEM.254-256.907].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/595947
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