All data obtained in experimental animal pain models support the role of nerve growth factor (NGF) as a putative candidate intervening in the pathogenesis of chronic pain, including chronic daily headache (CDH). Few studies have been carried out to establish its role in maintaining pain states in humans. The present study was aimed at investigating cerebrospinal fluid (CSF) levels of NGF and brain-derived neurotrophic factor (BDNF), both measured by sensitive immunoassay, in 20 chronic migraine (CM) patients and 20 patients affected by primary fibromyalgia syndrome (PFMS), compared with those of 20 age-matched control subjects. Significantly higher levels of both neurotrophins and glutamate were found. A significantly positive correlation emerged between CSF values of BDNF and those of NGF (r =.61, P <.001; r =.53, P <.01) and glutamate (r =.44, P <.02; r =.51, P <.01) in CM and PFMS patients, respectively. These findings suggest the possibility of a NGF-mediated up-regulation of BDNF involved in the pathophysiological events underlying long-term neuroplastic changes in persistent chronic painful conditions, such as CM and fibromyalgia. NGF might indirectly exert its effect through enhancing glutamatergic transmission via BDNF. The above mechanisms could account for sustained central sensitization in both chronic pain states.Perspective: This article presents findings of higher NGF and BDNF levels correlated to increased glutamate levels in the OF of both chronic migraine and fibromyalgia patients. This opens new insights into the pathogenic mechanisms of chronic pain and offers clinicians new therapeutic perspectives targeting the above mechanisms in both painful disorders. (C) 2007 by the American Pain Society.

Increased levels of Neurotrophins are not specific for chronic migraine: Evidence from primary fibromyalgia syndrome / P., Sarchielli; M. L., Mancini; A., Floridi; F., Coppola; C., Rossi; K., Nardi; M., Acciarresi; Pini, Luigi Alberto; P., Calabresi. - In: THE JOURNAL OF PAIN. - ISSN 1526-5900. - STAMPA. - 8:9(2007), pp. 737-745. [10.1016/j.jpain.2007.05.002]

Increased levels of Neurotrophins are not specific for chronic migraine: Evidence from primary fibromyalgia syndrome

PINI, Luigi Alberto;
2007

Abstract

All data obtained in experimental animal pain models support the role of nerve growth factor (NGF) as a putative candidate intervening in the pathogenesis of chronic pain, including chronic daily headache (CDH). Few studies have been carried out to establish its role in maintaining pain states in humans. The present study was aimed at investigating cerebrospinal fluid (CSF) levels of NGF and brain-derived neurotrophic factor (BDNF), both measured by sensitive immunoassay, in 20 chronic migraine (CM) patients and 20 patients affected by primary fibromyalgia syndrome (PFMS), compared with those of 20 age-matched control subjects. Significantly higher levels of both neurotrophins and glutamate were found. A significantly positive correlation emerged between CSF values of BDNF and those of NGF (r =.61, P <.001; r =.53, P <.01) and glutamate (r =.44, P <.02; r =.51, P <.01) in CM and PFMS patients, respectively. These findings suggest the possibility of a NGF-mediated up-regulation of BDNF involved in the pathophysiological events underlying long-term neuroplastic changes in persistent chronic painful conditions, such as CM and fibromyalgia. NGF might indirectly exert its effect through enhancing glutamatergic transmission via BDNF. The above mechanisms could account for sustained central sensitization in both chronic pain states.Perspective: This article presents findings of higher NGF and BDNF levels correlated to increased glutamate levels in the OF of both chronic migraine and fibromyalgia patients. This opens new insights into the pathogenic mechanisms of chronic pain and offers clinicians new therapeutic perspectives targeting the above mechanisms in both painful disorders. (C) 2007 by the American Pain Society.
2007
8
9
737
745
Increased levels of Neurotrophins are not specific for chronic migraine: Evidence from primary fibromyalgia syndrome / P., Sarchielli; M. L., Mancini; A., Floridi; F., Coppola; C., Rossi; K., Nardi; M., Acciarresi; Pini, Luigi Alberto; P., Calabresi. - In: THE JOURNAL OF PAIN. - ISSN 1526-5900. - STAMPA. - 8:9(2007), pp. 737-745. [10.1016/j.jpain.2007.05.002]
P., Sarchielli; M. L., Mancini; A., Floridi; F., Coppola; C., Rossi; K., Nardi; M., Acciarresi; Pini, Luigi Alberto; P., Calabresi
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/594992
Citazioni
  • ???jsp.display-item.citation.pmc??? 43
  • Scopus 134
  • ???jsp.display-item.citation.isi??? 113
social impact