A case of notalgia paresthesica in a 62-year-old woman is reported. The patient complained of a intense itching, and occasionally burning, brown macule of six years duration on the back. Histologic examination showed increased melanin deposition in the basal layer of epidermis, numerous dermal melanophages, and scattered necrotic keratinocytes in both the epidermis and stratum corneum.Immunohistochemistry on frozen section revealed normal number and distribution of nerve fibers reactive for the general neural markers PGP 9.5 and neuron- specific enolase, and for the neuropeptides substance P-, vasoactive intestinal peptide-,and neuropeptide Y. Topical treatment with capsaicin improved pruritus and paresthetic sensations.
Notalgia parestesica. Descrizione di un caso con studio immunoistochimico dell'innervazione cutanea / G., Girolomoni; R., Magni; Magnoni, Cristina; F., Fantini. - In: GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA. - ISSN 0392-0488. - STAMPA. - 127:(1992), pp. 553-556.
Notalgia parestesica. Descrizione di un caso con studio immunoistochimico dell'innervazione cutanea.
MAGNONI, Cristina;
1992
Abstract
A case of notalgia paresthesica in a 62-year-old woman is reported. The patient complained of a intense itching, and occasionally burning, brown macule of six years duration on the back. Histologic examination showed increased melanin deposition in the basal layer of epidermis, numerous dermal melanophages, and scattered necrotic keratinocytes in both the epidermis and stratum corneum.Immunohistochemistry on frozen section revealed normal number and distribution of nerve fibers reactive for the general neural markers PGP 9.5 and neuron- specific enolase, and for the neuropeptides substance P-, vasoactive intestinal peptide-,and neuropeptide Y. Topical treatment with capsaicin improved pruritus and paresthetic sensations.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
