Atopic dermatitis (AD) can be exacerbated by various factors, including emotional stress, scratching and sweating. The aim of the present study was to evaluate the hypothesis that the inflammatory reaction in AD is also neurogenic. For this purpose, the levels of vasoactive intestinal polypeptide were measured radioimmunologically in whole-tissue homogenates of lesional skin of 13 patients with atopic dermatitis. Radioimmunoassay was performed using an antiserum, AH78, recognizing the carboxy-terminal fragment vasoactive intestinal polypeptide (22-28). Vasoactive intestinal polypeptide immunoreactivity was detected in relatively low amounts in control skin (0.428 +/- 0.08 pmol/g tissue), whereas a marked increase in the peptide was observed in lesional skin of patients with atopic dermatitis (5.62 +/- 1.25 pmol/g tissue). These results seem to suggest that vasoactive intestinal polypeptide could have a pathogenetic relevance in skin lesions of atopic dermatitis.

Skin Levels Of Vasoactive Intestinal Polypeptide In Atopic-Dermatitis / Pincelli, Carlo; F., Fantini; P., Romualdi; G., Lesa; Giannetti, Alberto. - In: ARCHIVES OF DERMATOLOGICAL RESEARCH. - ISSN 0340-3696. - STAMPA. - 283:(1991), pp. 230-232.

Skin Levels Of Vasoactive Intestinal Polypeptide In Atopic-Dermatitis

PINCELLI, Carlo;GIANNETTI, Alberto
1991

Abstract

Atopic dermatitis (AD) can be exacerbated by various factors, including emotional stress, scratching and sweating. The aim of the present study was to evaluate the hypothesis that the inflammatory reaction in AD is also neurogenic. For this purpose, the levels of vasoactive intestinal polypeptide were measured radioimmunologically in whole-tissue homogenates of lesional skin of 13 patients with atopic dermatitis. Radioimmunoassay was performed using an antiserum, AH78, recognizing the carboxy-terminal fragment vasoactive intestinal polypeptide (22-28). Vasoactive intestinal polypeptide immunoreactivity was detected in relatively low amounts in control skin (0.428 +/- 0.08 pmol/g tissue), whereas a marked increase in the peptide was observed in lesional skin of patients with atopic dermatitis (5.62 +/- 1.25 pmol/g tissue). These results seem to suggest that vasoactive intestinal polypeptide could have a pathogenetic relevance in skin lesions of atopic dermatitis.
1991
283
230
232
Skin Levels Of Vasoactive Intestinal Polypeptide In Atopic-Dermatitis / Pincelli, Carlo; F., Fantini; P., Romualdi; G., Lesa; Giannetti, Alberto. - In: ARCHIVES OF DERMATOLOGICAL RESEARCH. - ISSN 0340-3696. - STAMPA. - 283:(1991), pp. 230-232.
Pincelli, Carlo; F., Fantini; P., Romualdi; G., Lesa; Giannetti, Alberto
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/592765
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 29
  • ???jsp.display-item.citation.isi??? 22
social impact