Nerve growth factor (NGF) is a neurotrophic polypeptide required for the survival and differentiation of sensory and sympathetic neurons (1, 2). NGF belongs to a small family of structurally and functionally related proteins termed neurotrophins (NTs), which include brain-derived neurotrophic factor (BDNF) (3), NT-3 (4) and NT-4/5 (5). All neurotrophic molecules exert their effect by binding two classes of transmembrane receptors. A low affinity receptor of similar to 75 kD (p75) (6), and a high affinity, tyrosine kinase receptor, of similar to 140 kD that belongs to the trk family of receptors (7, 8).
Nerve growth factor and the skin / Pincelli, Carlo; M., Yaar. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - STAMPA. - 10:(1997), pp. 73-76.
Nerve growth factor and the skin
PINCELLI, Carlo;
1997
Abstract
Nerve growth factor (NGF) is a neurotrophic polypeptide required for the survival and differentiation of sensory and sympathetic neurons (1, 2). NGF belongs to a small family of structurally and functionally related proteins termed neurotrophins (NTs), which include brain-derived neurotrophic factor (BDNF) (3), NT-3 (4) and NT-4/5 (5). All neurotrophic molecules exert their effect by binding two classes of transmembrane receptors. A low affinity receptor of similar to 75 kD (p75) (6), and a high affinity, tyrosine kinase receptor, of similar to 140 kD that belongs to the trk family of receptors (7, 8).
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