Neuronal networks in the hippocampal and parahippocampal regions are damaged in patients affected by temporallobe epilepsy (TLE). The consequences of the lesions are still poorly understood, but evidence suggests thatinteractions between the entorhinal cortex (EC) and hippocampus are changed from polysynaptic to monosynaptic,bypassing the CA3 region. In addition, the perirhinal/postrhinal cortex (PC), which normally filters the signalsentering the hippocampal formation, may lose its capacity to inhibit the paroxysmal neuronal activity directed to orleaving the EC. Finally, emphasis has recently been placed on the epileptogenic role of the subiculum that isdisinhibited both in epileptic animals and in TLE patients.

Network interactions in the limbic system and epileptiform synchronization / M., Avoli; Biagini, Giuseppe; L., Uva; M., de Curtis. - STAMPA. - 2:(2009), pp. 830-836. [10.1016/B978-012373961-2.00007-2]

Network interactions in the limbic system and epileptiform synchronization

BIAGINI, Giuseppe;
2009

Abstract

Neuronal networks in the hippocampal and parahippocampal regions are damaged in patients affected by temporallobe epilepsy (TLE). The consequences of the lesions are still poorly understood, but evidence suggests thatinteractions between the entorhinal cortex (EC) and hippocampus are changed from polysynaptic to monosynaptic,bypassing the CA3 region. In addition, the perirhinal/postrhinal cortex (PC), which normally filters the signalsentering the hippocampal formation, may lose its capacity to inhibit the paroxysmal neuronal activity directed to orleaving the EC. Finally, emphasis has recently been placed on the epileptogenic role of the subiculum that isdisinhibited both in epileptic animals and in TLE patients.
2009
The Encyclopedia of Basic Epilepsy Research
9780123736888
Elsevier
PAESI BASSI
Network interactions in the limbic system and epileptiform synchronization / M., Avoli; Biagini, Giuseppe; L., Uva; M., de Curtis. - STAMPA. - 2:(2009), pp. 830-836. [10.1016/B978-012373961-2.00007-2]
M., Avoli; Biagini, Giuseppe; L., Uva; M., de Curtis
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/591971
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