The mechanism of action of interferon-alpha (IFN-A) in chronic myelogenous leukemia (CML) is not known, but some evidence points at the immune modulation properties of IFN-A. We conducted a prospective analysis on 49 patients with CML in chronic phase treated with IFN-A in order to identify the effect of therapy on different lymphocyte subpopulations as determined by flow cytometric quantification and whether this effect is associated with the response to IFN-A. The absolute number of lymphocytes was similar in all patients regardless of response to IFN-A. In patients achieving a complete cytogenetic response (CCGR) there was a rebound of the absolute count of CD3+, CD4+, CD8+, and CD19+ lymphocytes after discontinuation of therapy with IFN-A. Patients with resistant disease, as well as patients with hematologic response but no cytogenetic response, showed a lower absolute number of CD19+ cells than patients with any cytogenetic response. Patients who achieved a CCGR had a higher absolute number of CD56+ cells than patients with lesser response or no response to IFN-A, and this persisted after discontinuation of therapy. We conclude that an increase in absolute number of CD19+ and CD56+ lymphocytes is observed in CML patients achieving a CCGR with IFN-A compared to patients with lesser responses. These changes could have functional consequences in the control of the disease.

Effects of interferon-alpha therapy on lymphocyte subpopulations in patients with chronic myeloid leukemia / Sacchi, Stefano; Cortes, J; Kantarjian, H; Talpaz, M.. - In: HEMATOPATHOLOGY AND MOLECULAR HEMATOLOGY. - ISSN 1082-8893. - STAMPA. - 11(1):(1997), pp. 41-47.

Effects of interferon-alpha therapy on lymphocyte subpopulations in patients with chronic myeloid leukemia.

SACCHI, Stefano;
1997

Abstract

The mechanism of action of interferon-alpha (IFN-A) in chronic myelogenous leukemia (CML) is not known, but some evidence points at the immune modulation properties of IFN-A. We conducted a prospective analysis on 49 patients with CML in chronic phase treated with IFN-A in order to identify the effect of therapy on different lymphocyte subpopulations as determined by flow cytometric quantification and whether this effect is associated with the response to IFN-A. The absolute number of lymphocytes was similar in all patients regardless of response to IFN-A. In patients achieving a complete cytogenetic response (CCGR) there was a rebound of the absolute count of CD3+, CD4+, CD8+, and CD19+ lymphocytes after discontinuation of therapy with IFN-A. Patients with resistant disease, as well as patients with hematologic response but no cytogenetic response, showed a lower absolute number of CD19+ cells than patients with any cytogenetic response. Patients who achieved a CCGR had a higher absolute number of CD56+ cells than patients with lesser response or no response to IFN-A, and this persisted after discontinuation of therapy. We conclude that an increase in absolute number of CD19+ and CD56+ lymphocytes is observed in CML patients achieving a CCGR with IFN-A compared to patients with lesser responses. These changes could have functional consequences in the control of the disease.
1997
11(1)
41
47
Effects of interferon-alpha therapy on lymphocyte subpopulations in patients with chronic myeloid leukemia / Sacchi, Stefano; Cortes, J; Kantarjian, H; Talpaz, M.. - In: HEMATOPATHOLOGY AND MOLECULAR HEMATOLOGY. - ISSN 1082-8893. - STAMPA. - 11(1):(1997), pp. 41-47.
Sacchi, Stefano; Cortes, J; Kantarjian, H; Talpaz, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/585719
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