Four newly synthesized molecules derived from pyrazole-pyrimidine were assayed on Botrytis cinerea (Micheli), Fusarium moniliforme (Sheld) and Pythium ultimum (Trow). All proved effective in inhibiting the growth of the phytopathogens at all test concentrations (10, 20, 50, 100 µg/ml). The most effective compound was 1-(3)nitrophenyl-6-trifluoromethylpyrazolo3,4-dpyrimidine-4(5H)-thione (CF33). Ultrastructural studies on P. ultimum treated with CF33 revealed alterations in the normal hyphal shape and at high concentration, plasmolysis and damage to the wall texture was observed. At 20 µg/ml different vesicles were seen in the cytoplasm: some appeared quite dense, and specific cytochemical reactions indicated that they were most likely peroxysomes; other vesicles seem to be vacuoles of varying content. In some cases there was disintegration of the nuclear envelope. Effects on membrane lipids and interference in protein synthesis are hypothesized as possible mechanism of action of the molecule

Effectiveness of Four New Pyrazole-Pyrimidines on Phytopathogens: Ultrastructural Evidences on Pythium ultimum / Mares, D; Romagnoli, Carlo; Sacchetti, G; Bruni, A; AND VICENTINI, C. B.. - In: JOURNAL OF PHYTOPATHOLOGY. - ISSN 0931-1785. - STAMPA. - 148:7-8(2000), pp. 395-403. [10.1046/j.1439-0434.2000.00526.x]

Effectiveness of Four New Pyrazole-Pyrimidines on Phytopathogens: Ultrastructural Evidences on Pythium ultimum

ROMAGNOLI, Carlo;
2000

Abstract

Four newly synthesized molecules derived from pyrazole-pyrimidine were assayed on Botrytis cinerea (Micheli), Fusarium moniliforme (Sheld) and Pythium ultimum (Trow). All proved effective in inhibiting the growth of the phytopathogens at all test concentrations (10, 20, 50, 100 µg/ml). The most effective compound was 1-(3)nitrophenyl-6-trifluoromethylpyrazolo3,4-dpyrimidine-4(5H)-thione (CF33). Ultrastructural studies on P. ultimum treated with CF33 revealed alterations in the normal hyphal shape and at high concentration, plasmolysis and damage to the wall texture was observed. At 20 µg/ml different vesicles were seen in the cytoplasm: some appeared quite dense, and specific cytochemical reactions indicated that they were most likely peroxysomes; other vesicles seem to be vacuoles of varying content. In some cases there was disintegration of the nuclear envelope. Effects on membrane lipids and interference in protein synthesis are hypothesized as possible mechanism of action of the molecule
2000
148
7-8
395
403
Effectiveness of Four New Pyrazole-Pyrimidines on Phytopathogens: Ultrastructural Evidences on Pythium ultimum / Mares, D; Romagnoli, Carlo; Sacchetti, G; Bruni, A; AND VICENTINI, C. B.. - In: JOURNAL OF PHYTOPATHOLOGY. - ISSN 0931-1785. - STAMPA. - 148:7-8(2000), pp. 395-403. [10.1046/j.1439-0434.2000.00526.x]
Mares, D; Romagnoli, Carlo; Sacchetti, G; Bruni, A; AND VICENTINI, C. B.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/585550
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