The thiophene 5-(4-hydroxy-1-butinyl)2,2[prime prime or minute]-bithienyl (BBTOH) strongly inhibited in vitro eight different dermatophytes. Epidermophyton floccosum proved most sensitive to all doses of BBTOH when applied in conjunction with uv-A irradiation. BBTOH also proved quite active against Nannizia cajetani, the only dermatophyte which was also strongly inhibited when treated (50 [mu]g ml[minus sign]1) and kept in the dark. For this reason, N. cajetani was chosen as the test organism for TEM and SEM aimed at determining what treatment-induced ultrastructural and morphological modifications had occurred. TEM revealed that the photoactive mechanism of BBTOH was similar to that of 2,2[prime prime or minute][ratio]5[prime prime or minute],2[double prime or second]-terthienyl ([alpha]-T). SEM, on the other hand, showed that early culture aging resulted from treatment.

The photodynamic effect of 5-(4-hydroxy-1-butinyl)-2,2’-bithienyl on dermatophytes / Romagnoli, Carlo; Mares, D; Sacchetti, G. AND BRUNI A.. - In: MYCOLOGICAL RESEARCH. - ISSN 0953-7562. - STAMPA. - 102:(1998), pp. 1519-1524.

The photodynamic effect of 5-(4-hydroxy-1-butinyl)-2,2’-bithienyl on dermatophytes

ROMAGNOLI, Carlo;
1998

Abstract

The thiophene 5-(4-hydroxy-1-butinyl)2,2[prime prime or minute]-bithienyl (BBTOH) strongly inhibited in vitro eight different dermatophytes. Epidermophyton floccosum proved most sensitive to all doses of BBTOH when applied in conjunction with uv-A irradiation. BBTOH also proved quite active against Nannizia cajetani, the only dermatophyte which was also strongly inhibited when treated (50 [mu]g ml[minus sign]1) and kept in the dark. For this reason, N. cajetani was chosen as the test organism for TEM and SEM aimed at determining what treatment-induced ultrastructural and morphological modifications had occurred. TEM revealed that the photoactive mechanism of BBTOH was similar to that of 2,2[prime prime or minute][ratio]5[prime prime or minute],2[double prime or second]-terthienyl ([alpha]-T). SEM, on the other hand, showed that early culture aging resulted from treatment.
1998
102
1519
1524
The photodynamic effect of 5-(4-hydroxy-1-butinyl)-2,2’-bithienyl on dermatophytes / Romagnoli, Carlo; Mares, D; Sacchetti, G. AND BRUNI A.. - In: MYCOLOGICAL RESEARCH. - ISSN 0953-7562. - STAMPA. - 102:(1998), pp. 1519-1524.
Romagnoli, Carlo; Mares, D; Sacchetti, G. AND BRUNI A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/585543
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