Interleukin (IL)-10 is expressed in many solid tumours and plays an ambiguous role in controlling cancer growth and metastasis. In order to determine whether IL-10 is involved in tumour progression and prognosis in nonsmall cell lung cancer (NSCLC), IL-10 expression in tumour cells and tumour-associated macrophages (TAMs) and its associations, if any, with clinicopathological features were investigated. Paraffin-embedded sections of surgical specimens obtained from 50 patients who had undergone surgery for NSCLC were immunostained with an antibody directed against IL-10. TAMs and tumour cells positive for IL-10 were subsequently quantified. IL-10-positive TAM percentage was higher in patients with stage II, III and IV NSCLC, and in those with lymph node metastases compared with patients with stage I NSCLC. High IL-10 expression by TAMs was a significant independent predictor of advanced tumour stage, and thus was associated with worse overall survival. Conversely, IL-10 expression by tumour cells did not differ between stages II, III and IV and stage I NSCLC. In conclusion, interleukin-10 expression by tumour-associated macrophages, but not by tumour cells, may play a role in the progression and prognosis of nonsmall cell lung cancer. These results may be useful in the development of novel approaches for anticancer treatments.

Macrophage expression of interleukin-10 is a prognostic factor in nonsmall cell lung cancer / E., Zeni; L., Mazzetti; D., Miotto; N., LO CASCIO; P., Maestrelli; P., Querzoli; M., Pedriali; E., DE ROSA; Fabbri, Leonardo; C. E., Mapp; P., Boschetto. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - STAMPA. - 30:(2007), pp. 627-632. [10.1183/09031936.00129306]

Macrophage expression of interleukin-10 is a prognostic factor in nonsmall cell lung cancer

FABBRI, Leonardo;
2007

Abstract

Interleukin (IL)-10 is expressed in many solid tumours and plays an ambiguous role in controlling cancer growth and metastasis. In order to determine whether IL-10 is involved in tumour progression and prognosis in nonsmall cell lung cancer (NSCLC), IL-10 expression in tumour cells and tumour-associated macrophages (TAMs) and its associations, if any, with clinicopathological features were investigated. Paraffin-embedded sections of surgical specimens obtained from 50 patients who had undergone surgery for NSCLC were immunostained with an antibody directed against IL-10. TAMs and tumour cells positive for IL-10 were subsequently quantified. IL-10-positive TAM percentage was higher in patients with stage II, III and IV NSCLC, and in those with lymph node metastases compared with patients with stage I NSCLC. High IL-10 expression by TAMs was a significant independent predictor of advanced tumour stage, and thus was associated with worse overall survival. Conversely, IL-10 expression by tumour cells did not differ between stages II, III and IV and stage I NSCLC. In conclusion, interleukin-10 expression by tumour-associated macrophages, but not by tumour cells, may play a role in the progression and prognosis of nonsmall cell lung cancer. These results may be useful in the development of novel approaches for anticancer treatments.
2007
30
627
632
Macrophage expression of interleukin-10 is a prognostic factor in nonsmall cell lung cancer / E., Zeni; L., Mazzetti; D., Miotto; N., LO CASCIO; P., Maestrelli; P., Querzoli; M., Pedriali; E., DE ROSA; Fabbri, Leonardo; C. E., Mapp; P., Boschetto. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - STAMPA. - 30:(2007), pp. 627-632. [10.1183/09031936.00129306]
E., Zeni; L., Mazzetti; D., Miotto; N., LO CASCIO; P., Maestrelli; P., Querzoli; M., Pedriali; E., DE ROSA; Fabbri, Leonardo; C. E., Mapp; P., Boschetto
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/584170
Citazioni
  • ???jsp.display-item.citation.pmc??? 39
  • Scopus 99
  • ???jsp.display-item.citation.isi??? 82
social impact