We report the occurrence of human herpesvirus (HHV)-8 primary infection in an adult male kidney recipient. Four months after transplantation, the patient developed visceral Kaposi sarcoma, and 1 month later he presented with progressive and severe peripheral cytopenia, in the presence of a normocellular or hypercellular bone marrow (BM) with hemophagocytosis. HHV-8 was the sole pathogen detected by polymerase chain reaction either in the serum or in the BM. HHV-8 latent nuclear antigen was detected in immature progenitor cells from the BM. Immunosuppressive therapy was reduced, and the patient was treated with foscarnet for 2 weeks, leading to a dramatic normalization of blood cell counts, concomitantly with the disappearance of HHV-8 viremia. At the end of antiviral therapy, the patient received chemotherapy, and Kaposi sarcoma regressed in 2 months. Severe peripheral cytopenia may be a post-transplant complication after HHV-8 infection, for which treatment with foscarnet seems appropriate.

Severe pancytopenia and hemophagocytosis after HHV-8 primary infection in a renal transplant patient successfully treated with foscarnet / Luppi, Mario; Barozzi, Patrizia; Rasini, V; Riva, Giovanni; Re, A; Rossi, Giorgio; Setti, G; Sandrini, S; Facchetti, F; Torelli, Giuseppe. - In: TRANSPLANTATION. - ISSN 0041-1337. - STAMPA. - 74:1(2002), pp. 131-133. [10.1097/00007890-200207150-00023]

Severe pancytopenia and hemophagocytosis after HHV-8 primary infection in a renal transplant patient successfully treated with foscarnet

LUPPI, Mario;BAROZZI, Patrizia;RIVA, Giovanni;ROSSI, Giorgio;TORELLI, Giuseppe
2002

Abstract

We report the occurrence of human herpesvirus (HHV)-8 primary infection in an adult male kidney recipient. Four months after transplantation, the patient developed visceral Kaposi sarcoma, and 1 month later he presented with progressive and severe peripheral cytopenia, in the presence of a normocellular or hypercellular bone marrow (BM) with hemophagocytosis. HHV-8 was the sole pathogen detected by polymerase chain reaction either in the serum or in the BM. HHV-8 latent nuclear antigen was detected in immature progenitor cells from the BM. Immunosuppressive therapy was reduced, and the patient was treated with foscarnet for 2 weeks, leading to a dramatic normalization of blood cell counts, concomitantly with the disappearance of HHV-8 viremia. At the end of antiviral therapy, the patient received chemotherapy, and Kaposi sarcoma regressed in 2 months. Severe peripheral cytopenia may be a post-transplant complication after HHV-8 infection, for which treatment with foscarnet seems appropriate.
2002
74
1
131
133
Severe pancytopenia and hemophagocytosis after HHV-8 primary infection in a renal transplant patient successfully treated with foscarnet / Luppi, Mario; Barozzi, Patrizia; Rasini, V; Riva, Giovanni; Re, A; Rossi, Giorgio; Setti, G; Sandrini, S; Facchetti, F; Torelli, Giuseppe. - In: TRANSPLANTATION. - ISSN 0041-1337. - STAMPA. - 74:1(2002), pp. 131-133. [10.1097/00007890-200207150-00023]
Luppi, Mario; Barozzi, Patrizia; Rasini, V; Riva, Giovanni; Re, A; Rossi, Giorgio; Setti, G; Sandrini, S; Facchetti, F; Torelli, Giuseppe
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/5766
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