The invention provides novel non-/9-lactam inhibitors of ^-lactamases. In particular, the invention provides such inhibitors which are boronic acids of formula (I) which is set forth in the specification. These compounds may be used with /Mactam antibiotics to treat /J-lactam-antibiotic-resistant bacterial infections. Finally, the invention provides a pharmaceutical composition comprising these compounds.
3-Aminophenylboronic acid derivative inhibitors of beta-lactamases, their preparation, and their therapeutic use / SHOICHET BRIAN, K.; Costi, Maria Paola; Tondi, Donatella. - (1998 Dec 16).
3-Aminophenylboronic acid derivative inhibitors of beta-lactamases, their preparation, and their therapeutic use.
COSTI, Maria Paola;TONDI, Donatella
1998
Abstract
The invention provides novel non-/9-lactam inhibitors of ^-lactamases. In particular, the invention provides such inhibitors which are boronic acids of formula (I) which is set forth in the specification. These compounds may be used with /Mactam antibiotics to treat /J-lactam-antibiotic-resistant bacterial infections. Finally, the invention provides a pharmaceutical composition comprising these compounds.
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