The cisplatin-resistant human breast cancer MCF7/CH cells have been shown to be also cross-resistant to the spermine analog N1-N12-bisethylspermine (BESPM) in comparison to their -sensitive counterparts, MCF7 cells. This cross-resistance was, at least in part, ascribable to the reduced induction of the polyamine key catabolic enzyme SSAT, which is one of the main target of this drug. As a consequence of this different induction of SSAT activity, the resistant cell line was less depleted of its polyamine content than the parental line, accounting for its better survival to the analog treatment.

Differential induction of spermidine/spermine N1-acetyltransferase in cisplatin-sensitive and -resistant human breast cancer cells by N1, N12-bis(ethyl)spermine / Marverti, Gaetano; G., Monti; M. G., Piccinini; And, Moruzzi; M., S.. - 3:(1999), pp. 94-98.

Differential induction of spermidine/spermine N1-acetyltransferase in cisplatin-sensitive and -resistant human breast cancer cells by N1, N12-bis(ethyl)spermine.

MARVERTI, Gaetano;
1999

Abstract

The cisplatin-resistant human breast cancer MCF7/CH cells have been shown to be also cross-resistant to the spermine analog N1-N12-bisethylspermine (BESPM) in comparison to their -sensitive counterparts, MCF7 cells. This cross-resistance was, at least in part, ascribable to the reduced induction of the polyamine key catabolic enzyme SSAT, which is one of the main target of this drug. As a consequence of this different induction of SSAT activity, the resistant cell line was less depleted of its polyamine content than the parental line, accounting for its better survival to the analog treatment.
1999
Biologically active amines in food processing and amines produced by bacteria, and polyamines and tumour growth
92-828-7008-1
Differential induction of spermidine/spermine N1-acetyltransferase in cisplatin-sensitive and -resistant human breast cancer cells by N1, N12-bis(ethyl)spermine / Marverti, Gaetano; G., Monti; M. G., Piccinini; And, Moruzzi; M., S.. - 3:(1999), pp. 94-98.
Marverti, Gaetano; G., Monti; M. G., Piccinini; And, Moruzzi; M., S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/462157
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