A useful synthesis of new dual-action cephalosporins is reported. These molecules could represent a fascinating tool for treatment of bacterial infectious diseases, since they display a possible inhibitor activity towards beta-lactamase-expressing bacteria. The major advantage of this 3-step synthetic approach lies in its versatility, which allows the systematic preparation of a wide pool of new molecules.
An efficient and versatile synthesis of new Trojan-horse cephalosporins / Spaggiari, Alberto; L. C., Blaszczak; Prati, Fabio. - In: ARS PHARMACEUTICA. - ISSN 0004-2927. - STAMPA. - 46:(2005), pp. 167-180.
An efficient and versatile synthesis of new Trojan-horse cephalosporins
SPAGGIARI, Alberto;PRATI, Fabio
2005
Abstract
A useful synthesis of new dual-action cephalosporins is reported. These molecules could represent a fascinating tool for treatment of bacterial infectious diseases, since they display a possible inhibitor activity towards beta-lactamase-expressing bacteria. The major advantage of this 3-step synthetic approach lies in its versatility, which allows the systematic preparation of a wide pool of new molecules.
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